{"doi":"10.3390/pathogens10020108","title":"Affecting the Effectors: Regulation of Legionella pneumophila Effector Function by Metaeffectors","abstract":"<jats:p>Many bacterial pathogens utilize translocated virulence factors called effectors to successfully infect their host. Within the host cell, effector proteins facilitate pathogen replication through subversion of host cell targets and processes. Legionella pneumophila is a Gram-negative intracellular bacterial pathogen that relies on hundreds of translocated effectors to replicate within host phagocytes. Within this large arsenal of translocated effectors is a unique subset of effectors called metaeffectors, which target and regulate other effectors. At least one dozen metaeffectors are encoded by L. pneumophila; however, mechanisms by which they promote virulence are largely unknown. This review details current knowledge of L pneumophila metaeffector function, challenges associated with their identification, and potential avenues to reveal the contribution of metaeffectors to bacterial pathogenesis.</jats:p>","journal":"Pathogens","year":2021,"id":654591,"datarank":0.515098080672772,"base_score":3.4339872044851463,"endowment":3.4339872044851463,"self_citation_contribution":0.515098080672772,"citation_network_contribution":0.0,"self_endowment_contribution":0.515098080672772,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":30,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":449817,"name":"Stephanie R. 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At least one dozen metaeffectors are encoded by L. pneumophila; however, mechanisms by which they promote virulence are largely unknown. This review details current knowledge of L pneumophila metaeffector function, challenges associated with their identification, and potential avenues to reveal the contribution of metaeffectors to bacterial pathogenesis.</jats:p>","is_dataset_classified":null,"base_score":3.367295829986474,"endowment":3.367295829986474,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33499048","pmcid":"PMC7911563","openalex_id":"https://openalex.org/W3122762908","authors":[],"funders":[{"funder_name":"National Institute of General Medical Sciences","grant_id":"P20GM130448","title":null},{"funder_name":"U.S. Department of Agriculture","grant_id":"3020-43440-001-00D","title":null},{"funder_name":"Kansas State University","grant_id":"Start-up funds","title":null},{"funder_name":"National Institutes of Health","grant_id":"1P20GM130448-01A1","title":"Center on Emerging and Zoonotic Infectious Diseases"}],"total_grants":4,"fwci":3.628,"citation_percentile":0.92720307,"influential_citations":0,"citation_trend":[{"year":2021,"count":2},{"year":2022,"count":6},{"year":2023,"count":4},{"year":2024,"count":8},{"year":2025,"count":3},{"year":2026,"count":5}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.mdpi.com/2076-0817/10/2/108/pdf?version=1611305705","host_type":"journal"},{"url":"https://www.mdpi.com/2076-0817/10/2/108/pdf?version=1611305705","host_type":"publisher"},{"url":"https://www.mdpi.com/2076-0817/10/2/108/pdf","host_type":"publisher"},{"url":"https://doi.org/10.3390/pathogens10020108","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/33499048","host_type":"repository"},{"url":"https://doaj.org/article/8c93f8897361435d8ff34699a723917d","host_type":"repository"},{"url":"https://dx.doi.org/10.3390/pathogens10020108","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7911563","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC7911563","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC7911563?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.3390/pathogens10020108","host_type":""}],"fields_of_study":["Legionella and Acanthamoeba research","Bacterial biofilms and quorum sensing","Antibiotic Resistance in Bacteria","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":[],"keywords":["Legionella pneumophila","Effector","Virulence","Biology","Legionella","Microbiology","Pathogen","Function (biology)","Cell biology","Bacteria","Gene","Genetics","Metaeffector","<i>Legionella pneumophila</i>","R","Medicine","Review"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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