{"doi":"10.3390/nu8110743","title":"Fish Consumption and Age-Related Macular Degeneration Incidence: A Meta-Analysis and Systematic Review of Prospective Cohort Studies","abstract":"<jats:p>The association between fish consumption and risk of age-related macular degeneration (AMD) is still unclear. The aim of the current meta-analysis and systematic review was to quantitatively evaluate findings from observational studies on fish consumption and the risk of AMD. Relevant studies were identified by searching electronic databases (Medline and EMBASE) and reviewing the reference lists of relevant articles up to August, 2016. Prospective cohort studies that reported relative risks (RRs) and 95% confidence intervals (CIs) for the link between fish consumption and risk of AMD were included. A total of 4202 cases with 128,988 individuals from eight cohort studies were identified in the current meta-analysis. The meta-analyzed RR was 0.76 (95% CI, 0.65–0.90) when any AMD was considered. Subgroup analyses by AMD stages showed that fish consumption would reduce the risk of both early (RR, 0.83; 95% CI, 0.72–0.96) and late (RR; 0.76; 95% CI, 0.60–0.97) AMD. When stratified by the follow-up duration, fish consumption was a protective factor of AMD in both over 10 years (n = 5; RR, 0.81; 95% CI, 0.67–0.97) and less than 10 years (n = 3; RR, 0.70; 95% CI, 0.51 to 0.97) follow-up duration. Stratified analyses by fish type demonstrated that dark meat fish (RR, 0.68, 95% CI, 0.46–0.99), especially tuna fish (RR, 0.58; 95% CI, 95% CI, 0.47–0.71) intake was associated with reduced AMD risk. Evidence of a linear association between dose of fish consumption and risk of AMD was demonstrated. The results of this meta-analysis demonstrated that fish consumption can reduce AMD risk. Advanced, well-designed, randomized clinical trials are required in order to validate the conclusions in this study.</jats:p>","journal":"Nutrients","year":2016,"id":16354,"datarank":1.5854996525811877,"base_score":3.7376696182833684,"endowment":3.7376696182833684,"self_citation_contribution":0.5606504427425053,"citation_network_contribution":1.0248492098386823,"self_endowment_contribution":0.5606504427425053,"citer_contribution":1.0248492098386823,"corpus_percentile":null,"corpus_rank":null,"citation_count":41,"citer_count":40,"citers_with_citation_signal":32,"citers_with_endowment":32,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":58894,"name":"Yan Wu","orcid":"0000-0002-8874-8886","position":1,"is_corresponding":false},{"id":121028,"name":"Yi-Fang Meng","orcid":null,"position":2,"is_corresponding":false},{"id":121029,"name":"Qian Xing","orcid":null,"position":3,"is_corresponding":false},{"id":121030,"name":"Jian-Jun Tao","orcid":null,"position":4,"is_corresponding":false},{"id":121031,"name":"Jiong Lu","orcid":null,"position":5,"is_corresponding":false},{"id":4626,"name":"Wei Zhu","orcid":"0000-0001-8802-0599","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":3.7376696182833684,"endowment":3.7376696182833684,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"27879656","pmcid":"PMC5133126","openalex_id":"https://openalex.org/W2556457354","authors":[],"funders":[],"total_grants":0,"fwci":3.3575,"citation_percentile":0.92108656,"influential_citations":0,"citation_trend":[{"year":2017,"count":3},{"year":2018,"count":4},{"year":2019,"count":4},{"year":2020,"count":6},{"year":2021,"count":7},{"year":2022,"count":5},{"year":2023,"count":7},{"year":2024,"count":4},{"year":2025,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.mdpi.com/2072-6643/8/11/743/pdf?version=1479805213","host_type":"journal"},{"url":"https://www.mdpi.com/2072-6643/8/11/743/pdf?version=1479805213","host_type":"GOLD"},{"url":"https://www.mdpi.com/2072-6643/8/11/743/pdf?version=1479805213","host_type":"publisher"},{"url":"https://www.mdpi.com/2072-6643/8/11/743/pdf","host_type":"publisher"},{"url":"https://doi.org/10.3390/nu8110743","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/27879656","host_type":"repository"},{"url":"https://doaj.org/article/8afe7e7838b34096a58ca8d6400fca94","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5133126","host_type":"repository"},{"url":"https://dx.doi.org/10.3390/nu8110743","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC5133126","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC5133126?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Retinal Diseases and Treatments","Antioxidant Activity and Oxidative Stress","Retinal Imaging and Analysis","Medicine","Environmental Science","Aged","Aged, 80 and over","Animals","Feeding Behavior","Female","Fishes","Humans","Incidence","Linear Models","Macular Degeneration","Male","Middle Aged","Observational Studies as Topic","Odds Ratio","Prospective Studies","Protective Factors","Risk Assessment","Risk Factors","Seafood","Time Factors"],"mesh_terms":["Aged","Aged, 80 and over","Animals","Feeding Behavior","Female","Fishes","Humans","Macular Degeneration","Male","Middle Aged","Prospective Studies","Risk Factors","Time Factors","Incidence","Linear Models","Odds Ratio","Seafood","Risk Assessment","Observational Studies as Topic","Protective Factors"],"keywords":["Relative risk","Medicine","Meta-analysis","Cohort study","Macular degeneration","Prospective cohort study","Incidence (geometry)","Confidence interval","Cohort","Lower risk","Internal medicine","Subgroup analysis","Ophthalmology","Nutrients","FISH","Age-related macular degeneration"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life below water"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-01T21:37:28.731477Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}