{"doi":"10.3390/nu15102416","title":"Omega-3 Fatty Acids Interact with DPP10 Region Genotype in Association with Childhood Atopy","abstract":"Associations of omega-3 fatty acids (n-3) with allergic diseases are inconsistent, perhaps in part due to genetic variation. We sought to identify and validate genetic variants that modify associations of n-3 with childhood asthma or atopy in participants in the Vitamin D Antenatal Asthma Reduction Trial (VDAART) and the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC). Dietary n-3 was derived from food frequency questionnaires and plasma n-3 was measured via untargeted mass spectrometry in early childhood and children aged 6 years old. Interactions of genotype with n-3 in association with asthma or atopy at age 6 years were sought for six candidate genes/gene regions and genome-wide. Two SNPs in the region of DPP10 (rs958457 and rs1516311) interacted with plasma n-3 at age 3 years in VDAART (p = 0.007 and 0.003, respectively) and with plasma n-3 at age 18 months in COPSAC (p = 0.01 and 0.02, respectively) in associationwith atopy. Another DPP10 region SNP, rs1367180, interacted with dietary n-3 at age 6 years in VDAART (p = 0.009) and with plasma n-3 at age 6 years in COPSAC (p = 0.004) in association with atopy. No replicated interactions were identified for asthma. The effect of n-3 on reducing childhood allergic disease may differ by individual factors, including genetic variation in the DPP10 region.","journal":"Nutrients","year":2023,"id":384966,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.955,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1152737,"name":"Kasper Fischer‐Rasmussen","orcid":"0009-0002-3191-1862","position":1,"is_corresponding":false},{"id":241476,"name":"Klaus Bønnelykke","orcid":"0000-0003-2003-1018","position":2,"is_corresponding":false},{"id":255256,"name":"Hans Bisgaard","orcid":"0000-0003-4131-7592","position":3,"is_corresponding":false},{"id":241480,"name":"Bo Chawes","orcid":"0000-0001-6846-6243","position":4,"is_corresponding":false},{"id":285327,"name":"Rachel S. Kelly","orcid":"0000-0003-3023-1822","position":5,"is_corresponding":false},{"id":218538,"name":"Jessica Lasky‐Su","orcid":"0000-0001-6236-4705","position":6,"is_corresponding":false},{"id":252197,"name":"Robert S. Zeiger","orcid":"0000-0001-5788-5063","position":7,"is_corresponding":false},{"id":91957,"name":"George O'connor","orcid":"0000-0002-6476-3926","position":8,"is_corresponding":false},{"id":110400,"name":"Leonard B. Bacharier","orcid":"0000-0003-0432-2704","position":9,"is_corresponding":false},{"id":11440,"name":"Vincent J. Carey","orcid":"0000-0003-4046-0063","position":10,"is_corresponding":false},{"id":252194,"name":"Nancy Laranjo","orcid":"0000-0002-0280-1405","position":11,"is_corresponding":false},{"id":252193,"name":"Augusto A. Litonjua","orcid":"0000-0003-0422-5875","position":12,"is_corresponding":false},{"id":25033,"name":"Scott T. Weiss","orcid":"0000-0001-7196-303X","position":13,"is_corresponding":false},{"id":285326,"name":"Kathleen Lee‐Sarwar","orcid":"0000-0003-0550-1640","position":0,"is_corresponding":true}],"reference_count":40,"raw_metadata":null,"created_at":"2026-07-19T01:17:48.629718Z","pmid":"37242299","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}