{"doi":"10.3390/nu15071791","title":"Estimated Phytate Intake Is Associated with Bone Mineral Density in Mediterranean Postmenopausal Women","abstract":"The main objective of this work was to explore the association of dietary phytate intake with bone mineral density (BMD) in a Mediterranean population of postmenopausal women. For this purpose, a cross-sectional analysis of 561 women aged 55–75 years with overweight/obesity and metabolic syndrome from a Mediterranean area and with data on dual-energy X-ray absorptiometry (DXA) scans in femur and lumbar spine was performed. Estimated phytate intake was calculated using a validated food frequency questionnaire. Our results indicated that phytate intake was associated with BMD [β(95%CI) per each 25 mg/100 kcal] in femoral neck [0.023(0.060–0.040) g/cm2], femoral Ward’s triangle [0.033(0.013–0.054) g/cm2], total femur [0.018(0.001–0.035) g/cm2], and all the analyzed lumbar spine sites [L1–L4: 0.033(0.007–0.059) g/cm2] after adjusting for potential confounders. The sensitivity analysis showed that phytate intake was directly associated with lumbar spine BMD in women younger than 66 years, with a body mass index higher than 32.6 kg/cm2 and without type 2 diabetes (all p-for interactions < 0.05). The overall results indicated that phytate, a substance present in food as cereals, legumes and nuts, was positively associated with BMD in Mediterranean postmenopausal women. Phytate may have a protective effect on bone resorption by adsorbing on the surfaces of HAP. Nevertheless, large, long-term, and randomized prospective clinical studies must be performed to assess the possible benefits of phytate consumption on BMD in postmenopausal women.","journal":"Nutrients","year":2023,"id":345903,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8968,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1085888,"name":"Rafael Prieto","orcid":"0000-0001-8814-900X","position":1,"is_corresponding":false},{"id":870133,"name":"Jadwiga Konieczna","orcid":"0000-0002-2947-1338","position":2,"is_corresponding":false},{"id":1085889,"name":"F. Gráses","orcid":"0000-0001-5636-9139","position":3,"is_corresponding":false},{"id":870152,"name":"Itziar Abete","orcid":"0000-0002-6475-5387","position":4,"is_corresponding":false},{"id":230964,"name":"Jordi Salas‐Salvadó","orcid":"0000-0003-2700-7459","position":5,"is_corresponding":false},{"id":83624,"name":"Vicente Martín","orcid":"0000-0003-0552-2804","position":6,"is_corresponding":false},{"id":230954,"name":"Miguel Ruiz‐Canela","orcid":"0000-0002-7684-2787","position":7,"is_corresponding":false},{"id":479595,"name":"Nancy Babió","orcid":"0000-0003-3527-5277","position":8,"is_corresponding":false},{"id":655423,"name":"Jesús García‐Gavilán","orcid":"0000-0002-3707-5255","position":9,"is_corresponding":false},{"id":855596,"name":"Albert Goday","orcid":null,"position":10,"is_corresponding":false},{"id":1085890,"name":"Antonia Costa‐Bauzá","orcid":"0000-0003-0647-4154","position":11,"is_corresponding":false},{"id":267387,"name":"J. Alfredo Martínéz","orcid":"0000-0001-5218-6941","position":12,"is_corresponding":false},{"id":39120,"name":"Dora Romaguera","orcid":"0000-0002-5762-8558","position":13,"is_corresponding":false},{"id":1085887,"name":"Pilar Sanchís","orcid":"0000-0001-8565-1811","position":0,"is_corresponding":true}],"reference_count":69,"raw_metadata":null,"created_at":"2026-07-19T01:11:44.152490Z","pmid":"37049631","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}