{"doi":"10.3390/nu14163251","title":"U-Shaped Relation of Dietary Thiamine Intake and New-Onset Hypertension","abstract":"Background: To examine the relation of dietary thiamine intake with risk of new-onset hypertension in the general adults. Methods: A total of 12,177 participants without hypertension at baseline from China Health and Nutrition Survey (CHNS) were included. The study outcome was new-onset hypertension, which was defined as a systolic blood pressure ≥140 mm Hg or a diastolic blood pressure ≥90 mm Hg or under antihypertensive treatment or diagnosed by physician during the follow-up. Results: A total of 4269 participants occurred new-onset hypertension over a median follow-up of 6.1 years. Overall, there was a U-shaped relation (p for nonlinearity <0.001) of dietary thiamine intake with new-onset hypertension, with an inflection point at 0.93 mg/day. Accordingly, in the threshold effect analysis, there was an inverse association between dietary thiamine intake (per SD increment: HR, 0.62; 95% CI: 0.53, 0.72) and new-onset hypertension in participants with dietary thiamine intake <0.93 mg/day, and a positive association between dietary thiamine intake (per SD increment: HR, 1.38; 95% CI: 1.32, 1.44) and new-onset hypertension in those with dietary thiamine intake ≥0.93 mg/day. Conclusion: The association between dietary thiamine intake and the risk of new-onset hypertension followed a U-shaped relation in the general Chinese population, with an inflection point at 0.93 mg/day of dietary thiamine intake.","journal":"Nutrients","year":2022,"id":271093,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9554,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":935912,"name":"Yanjun Zhang","orcid":"0000-0002-3123-1405","position":1,"is_corresponding":false},{"id":935913,"name":"Sisi Yang","orcid":"0009-0008-2696-9107","position":2,"is_corresponding":false},{"id":935914,"name":"Ziliang Ye","orcid":"0000-0001-8314-6977","position":3,"is_corresponding":false},{"id":935915,"name":"Qimeng Wu","orcid":"0000-0003-0562-7198","position":4,"is_corresponding":false},{"id":698328,"name":"Mengyi Liu","orcid":"0009-0008-9149-3272","position":5,"is_corresponding":false},{"id":320409,"name":"Chun Zhou","orcid":"0009-0009-0575-4841","position":6,"is_corresponding":false},{"id":320411,"name":"Panpan He","orcid":"0000-0003-4238-5837","position":7,"is_corresponding":false},{"id":935916,"name":"Jianping Jiang","orcid":"0000-0003-1120-6883","position":8,"is_corresponding":false},{"id":935917,"name":"Min Liang","orcid":"0000-0002-0613-2077","position":9,"is_corresponding":false},{"id":935918,"name":"Guobao Wang","orcid":"0000-0003-4050-3385","position":10,"is_corresponding":false},{"id":289676,"name":"Fan Fan Hou","orcid":"0000-0003-3117-7418","position":11,"is_corresponding":false},{"id":321926,"name":"Chengzhang Liu","orcid":null,"position":12,"is_corresponding":false},{"id":320414,"name":"Xianhui Qin","orcid":"0000-0001-7812-7982","position":13,"is_corresponding":false},{"id":320412,"name":"Yuanyuan Zhang","orcid":"0000-0002-9894-248X","position":0,"is_corresponding":true}],"reference_count":31,"raw_metadata":null,"created_at":"2026-07-19T00:27:35.206187Z","pmid":"36014758","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}