{"doi":"10.3390/nu14030469","title":"Simple Nutrient-Based Rules vs. a Nutritionally Rich Plant-Centered Diet in Prediction of Future Coronary Heart Disease and Stroke: Prospective Observational Study in the US","abstract":"To better understand nutrition paradigm shift from nutrients to foods and dietary patterns, we compared associations of a nutrient-based blood cholesterol-lowering diet vs. a food-based plant-centered diet with risk of coronary heart disease (CHD) and stroke. Participants were 4701 adults aged 18-30 years and free of cardiovascular disease at baseline, followed for clinical events from 1985 and 86 to 2018. A plant-centered diet was represented by higher A Priori Diet Quality Score (APDQS). A blood cholesterol-lowering diet was represented by lower Keys Score. Proportional hazards regression was used to calculate hazard ratios (HR). Higher APDQS showed a nutrient-dense composition that is low in saturated fat but high in fiber, vitamins and minerals. Keys Score and APDQS changes were each inversely associated with concurrent plasma low-density lipoprotein cholesterol (LDL-C) change. Over follow-up, 116 CHD and 80 stroke events occurred. LDL-C predicted CHD, but not stroke. APDQS, but not Keys Score, predicted lower risk of CHD and of stroke. Adjusted HRs (95% CIs) for each 1-SD higher APDQS were 0.73 (0.55-0.96) for CHD and 0.70 (0.50-0.99) for stroke. Neither low dietary fat nor low dietary carbohydrate predicted these events. Our findings support the ongoing shift in diet messages for cardiovascular prevention.","journal":"Nutrients","year":2022,"id":271396,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9475,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":452958,"name":"Daniel D. Gallaher","orcid":"0000-0002-5969-4938","position":1,"is_corresponding":false},{"id":936320,"name":"Karianne Svendsen","orcid":"0000-0002-7628-0999","position":2,"is_corresponding":false},{"id":348580,"name":"Katie A. Meyer","orcid":"0000-0001-7490-5273","position":3,"is_corresponding":false},{"id":451711,"name":"Lyn M. Steffen","orcid":"0000-0002-4053-6729","position":4,"is_corresponding":false},{"id":245375,"name":"Pamela J. Schreiner","orcid":"0000-0002-9920-6257","position":5,"is_corresponding":false},{"id":353721,"name":"James M. Shikany","orcid":"0000-0002-2424-9308","position":6,"is_corresponding":false},{"id":338873,"name":"Jamal S. Rana","orcid":"0000-0002-8222-3958","position":7,"is_corresponding":false},{"id":326797,"name":"Daniel Duprez","orcid":"0000-0002-0993-6839","position":8,"is_corresponding":false},{"id":65159,"name":"DAVID R. JACOBS","orcid":"0000-0002-7232-0543","position":9,"is_corresponding":false},{"id":871633,"name":"Yuni Choi","orcid":"0000-0003-0926-5331","position":0,"is_corresponding":true}],"reference_count":39,"raw_metadata":null,"created_at":"2026-07-19T00:27:35.206187Z","pmid":"35276828","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}