{"doi":"10.3390/nu13031029","title":"Low Carb and Ketogenic Diets Increase Quality of Life, Physical Performance, Body Composition, and Metabolic Health of Women with Breast Cancer","abstract":"<jats:p>Breast cancer (BC) patients often ask for a healthy diet. Here, we investigated a healthy standard diet (SD), a low carb diet (LCD), and a ketogenic diet (KD) for BC patients during the rehabilitation phase. KOLIBRI was an open-label non-randomized one-site nutritional intervention trial, combining inpatient and outpatient phases for 20 weeks. Female BC patients (n = 152; mean age 51.7 years) could select their diet. Data collected were: Quality of life (QoL), spiroergometry, body composition, and blood parameters. In total 30, 92, and 30 patients started the KD, LCD, and SD, respectively. Of those, 20, 76, and 25 completed the final examination. Patients rated all diets as feasible in daily life. All groups enhanced QoL, body composition, and physical performance. LCD participants showed the most impressive improvement in QoL aspects. KD participants finished with a very good physical performance and muscle/fat ratio. Despite increased cholesterol levels, KD patients had the best triglyceride/high-density lipoprotein (HDL) ratio and homeostatic model assessment of insulin resistance index (HOMA-IR). Most metabolic parameters significantly improved in the LCD group. SD participants ended with remarkably low cholesterol levels but did not improve triglyceride/HDL or HOMA-IR. In conclusion, both well-defined KDs and LCDs are safe and beneficial for BC patients and can be recommended during the rehabilitation phase.</jats:p>","journal":"Nutrients","year":2021,"id":646378,"datarank":0.5983476069846413,"base_score":3.9889840465642745,"endowment":3.9889840465642745,"self_citation_contribution":0.5983476069846413,"citation_network_contribution":0.0,"self_endowment_contribution":0.5983476069846413,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":53,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1683544,"name":"Rainer J. Klement","orcid":"0000-0003-1401-4270","position":1,"is_corresponding":false},{"id":1683545,"name":"Fabian T. Joos","orcid":null,"position":2,"is_corresponding":false},{"id":1683546,"name":"Marc Sütterlin","orcid":null,"position":3,"is_corresponding":false},{"id":1683547,"name":"Monika Reuss-Borst","orcid":null,"position":4,"is_corresponding":false},{"id":1683543,"name":"Ulrike Kämmerer","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Low Carb and Ketogenic Diets Increase Quality of Life, Physical Performance, Body Composition, and Metabolic Health of Women with Breast Cancer","abstract":"<jats:p>Breast cancer (BC) patients often ask for a healthy diet. Here, we investigated a healthy standard diet (SD), a low carb diet (LCD), and a ketogenic diet (KD) for BC patients during the rehabilitation phase. KOLIBRI was an open-label non-randomized one-site nutritional intervention trial, combining inpatient and outpatient phases for 20 weeks. Female BC patients (n = 152; mean age 51.7 years) could select their diet. Data collected were: Quality of life (QoL), spiroergometry, body composition, and blood parameters. In total 30, 92, and 30 patients started the KD, LCD, and SD, respectively. Of those, 20, 76, and 25 completed the final examination. Patients rated all diets as feasible in daily life. All groups enhanced QoL, body composition, and physical performance. LCD participants showed the most impressive improvement in QoL aspects. KD participants finished with a very good physical performance and muscle/fat ratio. Despite increased cholesterol levels, KD patients had the best triglyceride/high-density lipoprotein (HDL) ratio and homeostatic model assessment of insulin resistance index (HOMA-IR). Most metabolic parameters significantly improved in the LCD group. SD participants ended with remarkably low cholesterol levels but did not improve triglyceride/HDL or HOMA-IR. In conclusion, both well-defined KDs and LCDs are safe and beneficial for BC patients and can be recommended during the rehabilitation phase.</jats:p>","is_dataset_classified":null,"base_score":3.9889840465642745,"endowment":3.9889840465642745,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33806775","pmcid":"PMC8004887","openalex_id":"https://openalex.org/W3139143786","authors":[],"funders":[{"funder_name":"German Pension Fond Baden-Württemberg","grant_id":"no number available","title":null}],"total_grants":1,"fwci":4.9121,"citation_percentile":0.96447081,"influential_citations":0,"citation_trend":[{"year":2021,"count":2},{"year":2022,"count":14},{"year":2023,"count":11},{"year":2024,"count":16},{"year":2025,"count":8},{"year":2026,"count":2}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.mdpi.com/2072-6643/13/3/1029/pdf?version=1616487959","host_type":"journal"},{"url":"https://www.mdpi.com/2072-6643/13/3/1029/pdf?version=1616487959","host_type":"publisher"},{"url":"https://www.mdpi.com/2072-6643/13/3/1029/pdf","host_type":"publisher"},{"url":"https://doi.org/10.3390/nu13031029","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/33806775","host_type":"repository"},{"url":"https://doaj.org/article/f136bbad22614c84a95014d2c1d3181b","host_type":"repository"},{"url":"https://dx.doi.org/10.3390/nu13031029","host_type":"repository"},{"url":"https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/23420","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8004887","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC8004887","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC8004887?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Diet and metabolism studies","Nutritional Studies and Diet","Metabolism, Diabetes, and Cancer","Adult","Aged","Body Composition","Breast Neoplasms","Diet","Diet, Carbohydrate-Restricted","Diet, Ketogenic","Female","Humans","Lipoproteins, HDL","Middle Aged","Physical Functional Performance","Quality of Life","Surveys and Questionnaires","Triglycerides"],"mesh_terms":["Physical Functional Performance","Adult","Aged","Body Composition","Breast Neoplasms","Diet","Female","Humans","Lipoproteins, HDL","Middle Aged","Quality of Life","Surveys and Questionnaires","Triglycerides","Diet, Carbohydrate-Restricted","Diet, Ketogenic"],"keywords":["Ketogenic diet","Medicine","Triglyceride","Quality of life (healthcare)","Breast cancer","Homeostatic model assessment","Insulin resistance","Internal medicine","Physical therapy","Cancer","Cholesterol","Endocrinology","Physiology","Obesity","Nursing","Rehabilitation","Supportive Care","Low Carb Diet"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"nct"},{"name":"doi"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-09T12:58:21.349861Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}