{"doi":"10.3390/nu12123658","title":"Pro-Inflammatory Diet Is Associated with Adiposity during Childhood and with Adipokines and Inflammatory Markers at 11 Years in Mexican Children","abstract":"There is limited evidence about the inflammatory potential of diet in children. The aim of this study was to evaluate the association between the Children’s Dietary Inflammatory Index (C-DII) from 5 to 11 years with adiposity and inflammatory biomarkers in Mexican children. We analyzed 726 children from a birth cohort study with complete dietary information and measurements to evaluate adiposity at 5, 7 and 11 y and 286 children with IL-6, hsCRP, leptin and adiponectin information at 11 y. C-DII trajectories were estimated using latent class linear mixed models. We used linear mixed models for adiposity and logistic and multinomial regression for biomarkers. In girls, each one-point increase in C-DII score was associated with greater adiposity (abdominal-circumference 0.41%, p = 0.03; skinfold-sum 1.76%, p = 0.01; and BMI Z-score 0.05, p = 0.01). At 11 y the C-DII was associated with greater leptin (34% ≥ 13.0 ng/mL, p = 0.03) and hsCRP concentrations (29% ≥ 3.00 mg/L, p = 0.06) and lower adiponectin/leptin ratio (75% < 2.45, p = 0.02). C-DII trajectory 3 in boys was associated with a 75.2% (p < 0.01) increase in leptin concentrations and a 37.9% decrease (p = 0.02) in the adiponectin/leptin ratio. This study suggests that the inflammatory potential of diet may influence adiposity in girls and the homeostasis of adipose tissue and chronic subclinical inflammation in 11-year-old children.","journal":"Nutrients","year":2020,"id":98838,"datarank":0.519860385419959,"base_score":3.4657359027997265,"endowment":3.4657359027997265,"self_citation_contribution":0.519860385419959,"citation_network_contribution":0.0,"self_endowment_contribution":0.519860385419959,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":31,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9408,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":487056,"name":"Ana Carolina Ariza","orcid":"0000-0002-0302-4062","position":1,"is_corresponding":false},{"id":487057,"name":"Ivonne Ramírez‐Silva","orcid":"0000-0002-5863-1169","position":2,"is_corresponding":false},{"id":487058,"name":"Lilia S Pedraza","orcid":"0000-0001-9975-7035","position":3,"is_corresponding":false},{"id":487744,"name":"Juan Ángel Rivera Dommarco","orcid":null,"position":4,"is_corresponding":false},{"id":487059,"name":"Eduardo Ortiz‐Panozo","orcid":"0000-0002-3141-210X","position":5,"is_corresponding":false},{"id":399444,"name":"Elena Zambrano","orcid":"0000-0002-0362-9117","position":6,"is_corresponding":false},{"id":487060,"name":"Luis A. Reyes‐Castro","orcid":"0000-0003-0397-6810","position":7,"is_corresponding":false},{"id":336846,"name":"Nitin Shivappa","orcid":"0000-0003-0441-8896","position":8,"is_corresponding":false},{"id":336847,"name":"James R. Hébert","orcid":"0000-0002-0677-2672","position":9,"is_corresponding":false},{"id":38911,"name":"Reynaldo Martorell","orcid":"0000-0001-8862-7243","position":10,"is_corresponding":false},{"id":39202,"name":"Aryeh D. Stein","orcid":"0000-0003-1138-6458","position":11,"is_corresponding":false},{"id":487061,"name":"Albino Barraza‐Villarreal","orcid":"0000-0002-9020-4175","position":12,"is_corresponding":false},{"id":23250,"name":"Isabelle Romieu","orcid":"0000-0002-8552-5273","position":13,"is_corresponding":false},{"id":487062,"name":"Laura Ávila-Jiménez","orcid":"0000-0002-1388-3178","position":14,"is_corresponding":false},{"id":371409,"name":"Usha Ramakrishnan","orcid":"0000-0003-1694-1238","position":15,"is_corresponding":false},{"id":487055,"name":"Sofía Barragán-Vázquez","orcid":"0000-0002-5771-8780","position":0,"is_corresponding":true}],"reference_count":57,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T22:36:58.511143Z","pmid":"33261143","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}