{"doi":"10.3390/nu12103214","title":"Hepatoprotection by Traditional Essence of Ginseng against Carbon Tetrachloride—Induced Liver Damage","abstract":"<jats:p>The peroxide produced in the lipid metabolic process attacks liver cells and causes liver injury. Ginsenosides have been shown to have anti-oxidation abilities and to mend myocardial damage. This study evaluated the effect of traditional ginseng essence (TEG) in preventing chemical liver damage induced by carbon tetrachloride (CCl4). Forty 8-week-old male Sprague Dawley (SD) rats were divided into five groups: control, liver injury (CCl4), and TEG by oral gavage at 0.074, 0.149, or 0.298 g/kg/day for nine weeks. Liver injury biochemical indicators, antioxidant enzyme activity, and lipid contents in liver tissues were evaluated. The liver appearance was observed, and histopathological tests were conducted to estimate whether TEG-antagonized oxidants further ameliorated liver injury. The results show that, after supplementation of TEG for nine consecutive weeks and CCl4—induced liver injury for eight weeks, the levels of liver injury biochemical indicators in animal serum decreased significantly, and, in liver tissue, antioxidant activity was significantly improved and accumulation of lipids was decreased. Pathological sections exhibited reduced liver lipid accumulation and fibrosis. As discussed above, TEG can increase the antioxidant capacity in the liver and the maintenance of hepatocyte function, protecting the liver from chemical injury and improving healthcare.</jats:p>","journal":"Nutrients","year":2020,"id":653399,"datarank":0.4335557636844247,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"self_citation_contribution":0.4335557636844247,"citation_network_contribution":0.0,"self_endowment_contribution":0.4335557636844247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1704856,"name":"Chao-Yun Wang","orcid":null,"position":1,"is_corresponding":false},{"id":1704857,"name":"Mon-Chien Lee","orcid":null,"position":2,"is_corresponding":false},{"id":1704858,"name":"Chi-Chang Huang","orcid":null,"position":3,"is_corresponding":false},{"id":1704855,"name":"Yi-Ju Hsu","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Hepatoprotection by Traditional Essence of Ginseng against Carbon Tetrachloride—Induced Liver Damage","abstract":"<jats:p>The peroxide produced in the lipid metabolic process attacks liver cells and causes liver injury. Ginsenosides have been shown to have anti-oxidation abilities and to mend myocardial damage. This study evaluated the effect of traditional ginseng essence (TEG) in preventing chemical liver damage induced by carbon tetrachloride (CCl4). Forty 8-week-old male Sprague Dawley (SD) rats were divided into five groups: control, liver injury (CCl4), and TEG by oral gavage at 0.074, 0.149, or 0.298 g/kg/day for nine weeks. Liver injury biochemical indicators, antioxidant enzyme activity, and lipid contents in liver tissues were evaluated. The liver appearance was observed, and histopathological tests were conducted to estimate whether TEG-antagonized oxidants further ameliorated liver injury. The results show that, after supplementation of TEG for nine consecutive weeks and CCl4—induced liver injury for eight weeks, the levels of liver injury biochemical indicators in animal serum decreased significantly, and, in liver tissue, antioxidant activity was significantly improved and accumulation of lipids was decreased. Pathological sections exhibited reduced liver lipid accumulation and fibrosis. As discussed above, TEG can increase the antioxidant capacity in the liver and the maintenance of hepatocyte function, protecting the liver from chemical injury and improving healthcare.</jats:p>","is_dataset_classified":null,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33096694","pmcid":"PMC7594089","openalex_id":"https://openalex.org/W3093844182","authors":[],"funders":[{"funder_name":"National Taiwan Sport University","grant_id":"NTSU No.1071027","title":null}],"total_grants":1,"fwci":0.671,"citation_percentile":0.66481764,"influential_citations":0,"citation_trend":[{"year":2020,"count":1},{"year":2021,"count":2},{"year":2022,"count":5},{"year":2023,"count":1},{"year":2024,"count":2},{"year":2025,"count":4},{"year":2026,"count":2}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.mdpi.com/2072-6643/12/10/3214/pdf?version=1603275503","host_type":"journal"},{"url":"https://www.mdpi.com/2072-6643/12/10/3214/pdf?version=1603275503","host_type":"publisher"},{"url":"https://www.mdpi.com/2072-6643/12/10/3214/pdf","host_type":"publisher"},{"url":"https://doi.org/10.3390/nu12103214","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/33096694","host_type":"repository"},{"url":"https://doaj.org/article/7dc88c4c406c452d8780eb6bf89651a0","host_type":"repository"},{"url":"https://dx.doi.org/10.3390/nu12103214","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7594089","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC7594089","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC7594089?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Ginseng Biological Effects and Applications","Pharmacological Effects of Natural Compounds","Liver Disease Diagnosis and Treatment","Animals","Antioxidants","Carbon Tetrachloride","Chemical and Drug Induced Liver Injury","Ginsenosides","Lipid Metabolism","Liver","Liver Function Tests","Male","Organ Size","Panax","Phytotherapy","Rats","Rats, Sprague-Dawley"],"mesh_terms":["Animals","Antioxidants","Carbon Tetrachloride","Panax","Liver","Liver Function Tests","Male","Phytotherapy","Organ Size","Rats, Sprague-Dawley","Ginsenosides","Lipid Metabolism","Rats","Chemical and Drug Induced Liver Injury"],"keywords":["Carbon tetrachloride","Hepatoprotection","Liver injury","CCL4","Liver function","Antioxidant","Hepatocyte","Ginseng","Lipid peroxidation","Medicine","Liver function tests","Pharmacology","Internal medicine","Chemistry","Biochemistry","Pathology","Glutathione","Enzyme","Ginsenosides","Anti-oxidant"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T21:25:07.464602Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}