{"doi":"10.3390/nu12103161","title":"Metabolomic Associations with Serum Bone Turnover Markers","abstract":"Bone is a dynamic tissue that is in a constant state of remodeling. Bone turnover markers (BTMs), procollagen type I N-terminal propeptide (P1NP) and C-terminal telopeptides of type I collagen (CTX), provide sensitive measures of bone formation and resorption, respectively. This study used ultra-high-resolution metabolomics (HRM) to determine plasma metabolic pathways and targeted metabolites related to the markers of bone resorption and formation in adults. This cross-sectional clinical study included 34 adults (19 females, mean 27.8 years), without reported illnesses, recruited from a US metropolitan area. Serum BTM levels were quantified by an ELISA. Plasma HRM utilized dual-column liquid chromatography and mass spectrometry to identify metabolites and metabolic pathways associated with BTMs. Metabolites significantly associated with P1NP (p < 0.05) were significantly enriched in pathways linked to the TCA cycle, pyruvate metabolism, and metabolism of B vitamins important for energy production (e.g., niacin, thiamin). Other nutrition-related metabolic pathways associated with P1NP were amino acid (proline, arginine, glutamate) and vitamin C metabolism, which are important for collagen formation. Metabolites associated with CTX levels (p < 0.05) were enriched within lipid and fatty acid beta-oxidation metabolic pathways, as well as fat-soluble micronutrient pathways including, vitamin D metabolism, vitamin E metabolism, and bile acid biosynthesis. P1NP and CTX were significantly related to microbiome-related metabolites (p < 0.05). Macronutrient-related pathways including lipid, carbohydrate, and amino acid metabolism, as well as several gut microbiome-derived metabolites were significantly related to BTMs. Future research should compare metabolism BTMs relationships reported here to aging and clinical populations to inform targeted therapeutic interventions.","journal":"Nutrients","year":2020,"id":63964,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":40,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9555,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":338673,"name":"Joseph L. Roberts","orcid":"0000-0001-6839-1173","position":1,"is_corresponding":false},{"id":231483,"name":"Dean P. Jones","orcid":"0000-0002-2090-0677","position":2,"is_corresponding":false},{"id":246041,"name":"Ken Liu","orcid":"0000-0002-9736-5828","position":3,"is_corresponding":false},{"id":338674,"name":"Kaitlin R. Taibl","orcid":"0000-0003-3828-2544","position":4,"is_corresponding":false},{"id":246042,"name":"Karan Uppal","orcid":"0000-0001-5985-1668","position":5,"is_corresponding":false},{"id":251683,"name":"M. Neale Weitzmann","orcid":"0000-0003-3305-5748","position":6,"is_corresponding":false},{"id":251685,"name":"Roberto Pacifici","orcid":"0000-0001-6077-8250","position":7,"is_corresponding":false},{"id":309043,"name":"Hicham Drissi","orcid":"0000-0002-3322-281X","position":8,"is_corresponding":false},{"id":320518,"name":"Thomas R. Ziegler","orcid":"0000-0001-9329-1481","position":9,"is_corresponding":false},{"id":279559,"name":"Jessica A. Alvarez","orcid":"0000-0002-7612-1162","position":10,"is_corresponding":false},{"id":338672,"name":"Moriah P. Bellissimo","orcid":"0000-0002-8998-4792","position":0,"is_corresponding":true}],"reference_count":74,"raw_metadata":null,"created_at":"2026-07-18T21:12:32.635050Z","pmid":"33081124","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}