{"doi":"10.3390/nu12102924","title":"Improvement in Uncontrolled Eating Behavior after Laparoscopic Sleeve Gastrectomy Is Associated with Alterations in the Brain–Gut–Microbiome Axis in Obese Women","abstract":"Background: Bariatric surgery is proven to change eating behavior and cause sustained weight loss, yet the exact mechanisms underlying these changes are not clearly understood. We explore this in a novel way by examining how bariatric surgery affects the brain–gut–microbiome (BGM) axis. Methods: Patient demographics, serum, stool, eating behavior questionnaires, and brain magnetic resonance imaging (MRI) were collected before and 6 months after laparoscopic sleeve gastrectomy (LSG). Differences in eating behavior and brain morphology and resting-state functional connectivity in core reward regions were correlated with serum metabolite and 16S microbiome data. Results: LSG resulted in significant weight loss and improvement in maladaptive eating behaviors as measured by the Yale Food Addiction Scale (YFAS). Brain imaging showed a significant increase in brain volume of the putamen (p.adj < 0.05) and amygdala (p.adj < 0.05) after surgery. Resting-state connectivity between the precuneus and the putamen was significantly reduced after LSG (p.adj = 0.046). This change was associated with YFAS symptom count. Bacteroides, Ruminococcus, and Holdemanella were associated with reduced connectivity between these areas. Metabolomic profiles showed a positive correlation between this brain connection and a phosphatidylcholine metabolite. Conclusion: Bariatric surgery modulates brain networks that affect eating behavior, potentially through effects on the gut microbiota and its metabolites.","journal":"Nutrients","year":2020,"id":92999,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":41,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8592,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":339221,"name":"Arpana Gupta","orcid":"0000-0002-1669-9624","position":1,"is_corresponding":false},{"id":36336,"name":"Jonathan P. Jacobs","orcid":"0000-0003-4698-0254","position":2,"is_corresponding":false},{"id":301054,"name":"Venu Lagishetty","orcid":"0000-0001-6500-8255","position":3,"is_corresponding":false},{"id":466339,"name":"Elizabeth Gallagher","orcid":null,"position":4,"is_corresponding":false},{"id":465016,"name":"Ravi R. Bhatt","orcid":"0000-0003-2498-8888","position":5,"is_corresponding":false},{"id":414454,"name":"Priten Vora","orcid":"0000-0001-8367-5377","position":6,"is_corresponding":false},{"id":465017,"name":"Vadim Osadchiy","orcid":"0000-0003-0492-9987","position":7,"is_corresponding":false},{"id":415137,"name":"Jean Stains","orcid":null,"position":8,"is_corresponding":false},{"id":466340,"name":"Anna Balioukova","orcid":null,"position":9,"is_corresponding":false},{"id":465018,"name":"Yijun Chen","orcid":"0000-0002-4920-152X","position":10,"is_corresponding":false},{"id":465019,"name":"Erik Dutson","orcid":"0000-0001-7126-1468","position":11,"is_corresponding":false},{"id":87732,"name":"Emeran A. Mayer","orcid":"0000-0003-3923-3349","position":12,"is_corresponding":false},{"id":466341,"name":"Claudia P. Sanmiguel","orcid":null,"position":13,"is_corresponding":false},{"id":301052,"name":"Tien S. Dong","orcid":"0000-0003-0105-8063","position":0,"is_corresponding":true}],"reference_count":83,"raw_metadata":null,"created_at":"2026-07-18T22:30:54.208860Z","pmid":"32987837","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}