{"doi":"10.3390/nu12041198","title":"Kokumi Taste Active Peptides Modulate Salt and Umami Taste","abstract":"Kokumi taste substances exemplified by γ-glutamyl peptides and Maillard Peptides modulate salt and umami tastes. However, the underlying mechanism for their action has not been delineated. Here, we investigated the effects of a kokumi taste active and inactive peptide fraction (500–10,000 Da) isolated from mature (FIIm) and immature (FIIim) Ganjang, a typical Korean soy sauce, on salt and umami taste responses in humans and rodents. Only FIIm (0.1–1.0%) produced a biphasic effect in rat chorda tympani (CT) taste nerve responses to lingual stimulation with 100 mM NaCl + 5 μM benzamil, a specific epithelial Na+ channel blocker. Both elevated temperature (42 °C) and FIIm produced synergistic effects on the NaCl + benzamil CT response. At 0.5% FIIm produced the maximum increase in rat CT response to NaCl + benzamil, and enhanced salt taste intensity in human subjects. At 2.5% FIIm enhanced rat CT response to glutamate that was equivalent to the enhancement observed with 1 mM IMP. In human subjects, 0.3% FIIm produced enhancement of umami taste. These results suggest that FIIm modulates amiloride-insensitive salt taste and umami taste at different concentration ranges in rats and humans.","journal":"Nutrients","year":2020,"id":57445,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":78,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9605,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":300576,"name":"Ah-Young Song","orcid":null,"position":1,"is_corresponding":false},{"id":37464,"name":"Eun Young Kim","orcid":"0000-0003-3525-8805","position":2,"is_corresponding":false},{"id":300577,"name":"Hee‐Jin Son","orcid":null,"position":3,"is_corresponding":false},{"id":299688,"name":"Yiseul Kim","orcid":"0000-0002-1749-230X","position":4,"is_corresponding":false},{"id":300578,"name":"Shobha Mummalaneni","orcid":null,"position":5,"is_corresponding":false},{"id":299689,"name":"Jie Qian","orcid":"0000-0002-2464-3006","position":6,"is_corresponding":false},{"id":299690,"name":"John R. Grider","orcid":"0000-0002-0268-8772","position":7,"is_corresponding":false},{"id":299691,"name":"Vijay Lyall","orcid":"0000-0001-6567-5023","position":8,"is_corresponding":false},{"id":299687,"name":"Mee‐Ra Rhyu","orcid":"0000-0002-1693-8330","position":0,"is_corresponding":true}],"reference_count":51,"raw_metadata":null,"created_at":"2026-07-18T21:06:31.136481Z","pmid":"32344605","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}