{"doi":"10.3390/nu12030749","title":"Comparison of Omega-3 Eicosapentaenoic Acid Versus Docosahexaenoic Acid-Rich Fish Oil Supplementation on Plasma Lipids and Lipoproteins in Normolipidemic Adults","abstract":"Background: Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have both shared and different cardiovascular effects, and commonly used fish oil supplements have considerably varied EPA/DHA ratios. Aims: We compared the effects of fish oil supplements with different EPA/DHA ratios on lipoprotein metabolism. Methods: In a double-blind, randomized cross-over study, normolipidemic adults (n = 30) consumed 12 g/day of EPA-rich (EPA/DHA: 2.3) or DHA-rich (EPA/DHA: 0.3) fish oil for 8-weeks, separated by an 8-week washout period. Results: Both fish oil supplements similarly lowered plasma TG levels and TG-related NMR parameters versus baseline (p < 0.05). There were no changes in plasma cholesterol-related parameters due to either fish oil, although on-treatment levels for LDL particle number were slightly higher for DHA-rich oil compared with EPA-rich oil (p < 0.05). Both fish oil supplements similarly altered HDL subclass profile and proteome, and down regulated HDL proteins related to inflammation, with EPA-rich oil to a greater extent. Furthermore, EPA-rich oil increased apoM abundance versus DHA-rich oil (p < 0.05). Conclusions: Overall, fish oil supplements with varied EPA/DHA ratios had similar effects on total lipids/lipoproteins, but differences were observed in lipoprotein subfraction composition and distribution, which could impact on the use of EPA versus DHA for improving cardiovascular health.","journal":"Nutrients","year":2020,"id":92362,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":42,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9529,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":311169,"name":"Marcelo Amar","orcid":"0000-0002-9097-2422","position":1,"is_corresponding":false},{"id":461866,"name":"Maureen Sampson","orcid":"0000-0003-0885-250X","position":2,"is_corresponding":false},{"id":270255,"name":"Amber B. Courville","orcid":"0000-0002-1419-3937","position":3,"is_corresponding":false},{"id":461867,"name":"Alexander V. Sorokin","orcid":"0000-0002-2291-4888","position":4,"is_corresponding":false},{"id":461868,"name":"Scott M. Gordon","orcid":"0000-0001-9532-032X","position":5,"is_corresponding":false},{"id":284425,"name":"Angel Aponte","orcid":"0000-0001-5684-2715","position":6,"is_corresponding":false},{"id":272692,"name":"Michael Stagliano","orcid":null,"position":7,"is_corresponding":false},{"id":284638,"name":"Martin P. Playford","orcid":"0000-0002-5571-7266","position":8,"is_corresponding":false},{"id":462692,"name":"Yi‐Ping Fu","orcid":null,"position":9,"is_corresponding":false},{"id":272693,"name":"Shanna Yang","orcid":null,"position":10,"is_corresponding":false},{"id":233337,"name":"Nehal N. Mehta","orcid":"0000-0003-4939-5130","position":11,"is_corresponding":false},{"id":311171,"name":"Alan T. Remaley","orcid":"0000-0003-2473-5549","position":12,"is_corresponding":false},{"id":352626,"name":"Zhihong Yang","orcid":"0000-0002-1885-3162","position":0,"is_corresponding":true}],"reference_count":45,"raw_metadata":null,"created_at":"2026-07-18T22:29:54.256205Z","pmid":"32178279","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}