{"doi":"10.3390/nano14191556","title":"All-Natural Gelatin-Based Nanoemulsion Loaded with TLR 7/8 Agonist for Efficient Modulation of Macrophage Polarization for Immunotherapy","abstract":"Macrophages are multifunctional immune cells essential for both innate and adaptive immune responses. Tumor-associated macrophages (TAMs) often adopt a tumor-promoting M2-like phenotype, aiding tumor progression and immune evasion. Reprogramming TAMs to a tumoricidal M1-like phenotype is an emerging target for cancer immunotherapy. Resiquimod, a TLR7/8 agonist, can repolarize macrophages from the M2- to M1-like phenotype but is limited by poor solubility. We developed a gelatin nanoemulsion for the loading and delivery of resiquimod, utilizing eugenol oil as the liquid phase and riboflavin-crosslinked gelatin as a scaffold. These nanoemulsions showed high stability, low toxicity, and effective macrophage repolarization, significantly enhancing pro-inflammatory markers and anticancer activity in co-culture models.","journal":"Nanomaterials","year":2024,"id":443340,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9518,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":668197,"name":"Ahmed Nabawy","orcid":"0000-0001-6505-4606","position":1,"is_corresponding":false},{"id":426194,"name":"Mingdi Jiang","orcid":"0000-0002-4742-405X","position":2,"is_corresponding":false},{"id":1027207,"name":"Yağız Anıl Çiçek","orcid":"0000-0003-3987-6969","position":3,"is_corresponding":false},{"id":1080548,"name":"Muhammad Aamir Hassan","orcid":"0009-0008-0524-9573","position":4,"is_corresponding":false},{"id":232160,"name":"Harini Nagaraj","orcid":"0000-0002-1615-9126","position":5,"is_corresponding":false},{"id":232159,"name":"Xianzhi Zhang","orcid":"0000-0002-9585-7458","position":6,"is_corresponding":false},{"id":232161,"name":"Vincent M. Rotello","orcid":"0000-0002-5184-5439","position":7,"is_corresponding":false},{"id":304708,"name":"Ritabrita Goswami","orcid":"0000-0003-3812-6322","position":0,"is_corresponding":true}],"reference_count":48,"raw_metadata":null,"created_at":"2026-07-19T02:01:24.471942Z","pmid":"39404283","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}