{"doi":"10.3390/molecules30183837","title":"SABRE Ir-IMes Catalysis for the Masses","abstract":"The Signal Amplification By Reversible Exchange (SABRE) technique provides enhancement of Nuclear Magnetic Resonance (NMR) signals up to several orders of magnitude using chemical exchange of a substrate and parahydrogen on an iridium complex. Therefore, the availability of such a catalytic complex to a broader community is an absolutely vital step for dissemination of the groundbreaking SABRE methodology. The most common SABRE catalyst, which is activated in situ, is based on Ir-IMes system (IMes = 1,3-Bis(2,4,6-trimethylphenyl)imidazol-2-ylidene). Earlier approaches for the synthesis of this catalyst often relied on specialized equipment and were limited to a comparatively small scale. This, in turn, increased the barrier of entry for new scientists to the area of SABRE hyperpolarization. Here, we present a robust, inexpensive, and easy to reproduce synthetic procedure for the preparation of this SABRE catalyst, which does not require specialized inert atmosphere equipment like a glove box or Schlenk line. The synthesis was validated on the scale of several grams vs. tens of milligrams scale in the reported approaches. The resulting SABRE catalyst, [Ir(IMes)(COD)Cl], was activated in situ and further evaluated in hyperpolarization experiments resulting in signal enhancements comparable to (or higher than) those for the catalyst prepared using Schlenk line equipment.","journal":"Molecules","year":2025,"id":518719,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.956,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1387084,"name":"Noah Terkildsen","orcid":null,"position":1,"is_corresponding":false},{"id":1386620,"name":"Zachary T. Bender","orcid":"0009-0005-0216-6623","position":2,"is_corresponding":false},{"id":1109974,"name":"Abubakar Abdurraheem","orcid":"0000-0002-3916-8834","position":3,"is_corresponding":false},{"id":866335,"name":"Shiraz Nantogma","orcid":"0000-0002-2655-6256","position":4,"is_corresponding":false},{"id":1077191,"name":"Anna Samoilenko","orcid":null,"position":5,"is_corresponding":false},{"id":1386621,"name":"Joseph Gyesi","orcid":"0000-0002-1672-0147","position":6,"is_corresponding":false},{"id":1210022,"name":"Larisa M. Kovtunova","orcid":"0000-0003-0922-6594","position":7,"is_corresponding":false},{"id":602381,"name":"Oleg G. Salnikov","orcid":"0000-0003-2266-7335","position":8,"is_corresponding":false},{"id":602377,"name":"Igor V. Koptyug","orcid":"0000-0003-3480-7649","position":9,"is_corresponding":false},{"id":1386622,"name":"Raphael Kircher","orcid":"0000-0002-7980-7995","position":10,"is_corresponding":false},{"id":602376,"name":"Danila A. Barskiy","orcid":"0000-0002-2819-7584","position":11,"is_corresponding":false},{"id":402028,"name":"Eduard Y. Chekmenev","orcid":"0000-0002-8745-8801","position":12,"is_corresponding":false},{"id":477784,"name":"Roman V. Shchepin","orcid":"0000-0001-9135-3036","position":13,"is_corresponding":false},{"id":1386619,"name":"Izabelle Smith","orcid":"0009-0005-0239-7624","position":0,"is_corresponding":true}],"reference_count":66,"raw_metadata":null,"created_at":"2026-07-19T02:49:14.184995Z","pmid":"41011729","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}