{"doi":"10.3390/molecules30030680","title":"Isolation and Bioassay of Linear Veraguamides from a Marine Cyanobacterium (Okeania sp.)","abstract":"Marine cyanobacteria have gained momentum in recent years as a source of novel bioactive small molecules. This paper describes the structure elucidation and pharmacological evaluation of two new (veraguamide O (1) and veraguamide P (2)) and one known (veraguamide C (3)) analogs isolated from a cyanobacterial collection made in the Las Perlas Archipelago of Panama. We hypothesized that these compounds would be cytotoxic in cancer cell lines. The compounds were screened against HEK-293, estrogen receptor positive (MCF-7), and triple-negative breast cancer (MDA-MB-231) cells as well as against a broad panel of membrane-bound receptors. The planar structures were determined based on NMR and MS data along with a comparison to previously isolated veraguamide analogs. Phylogenetic analysis of the collection suggests it to be an Okeania sp., a similar species to the cyanobacterium reported to produce other veraguamides. Veraguamide O shows no cytotoxicity (greater than 100 μM) against ER-positive cells (MCF-7) with 13 μM IC50 against MDA-MB-231 TNBC cells. Interestingly, these compounds show affinity for the sigma2/TMEM-97 receptor, making them potential leads for the development of non-toxic sigma 2 targeting ligands.","journal":"Molecules","year":2025,"id":550126,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9577,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1125833,"name":"Andrea Hough","orcid":null,"position":1,"is_corresponding":false},{"id":1444706,"name":"Thomas D. Wright","orcid":"0009-0007-6324-7464","position":2,"is_corresponding":false},{"id":1445467,"name":"Neil Lax","orcid":null,"position":3,"is_corresponding":false},{"id":1125452,"name":"Asef Faruk","orcid":"0000-0003-1702-9689","position":4,"is_corresponding":false},{"id":1419416,"name":"Christian K. Fofie","orcid":null,"position":5,"is_corresponding":false},{"id":1418910,"name":"Rebekah D. Simcik","orcid":"0009-0007-6006-7273","position":6,"is_corresponding":false},{"id":510661,"name":"Jane E. Cavanaugh","orcid":"0000-0001-6791-3574","position":7,"is_corresponding":false},{"id":313536,"name":"Benedict J. Kolber","orcid":"0000-0001-8665-1805","position":8,"is_corresponding":false},{"id":1102214,"name":"Kevin Tidgewell","orcid":"0000-0002-0501-2604","position":9,"is_corresponding":false},{"id":1445466,"name":"Stacy‐Ann J. Parker","orcid":null,"position":0,"is_corresponding":true}],"reference_count":38,"raw_metadata":null,"created_at":"2026-07-19T02:54:12.321988Z","pmid":"39942783","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}