{"doi":"10.3390/molecules29112691","title":"L-Theanine Prolongs the Lifespan by Activating Multiple Molecular Pathways in Ultraviolet C-Exposed Caenorhabditis elegans","abstract":"L-theanine, a unique non-protein amino acid, is an important bioactive component of green tea. Previous studies have shown that L-theanine has many potent health benefits, such as anti-anxiety effects, regulation of the immune response, relaxing neural tension, and reducing oxidative damage. However, little is known concerning whether L-theanine can improve the clearance of mitochondrial DNA (mtDNA) damage in organisms. Here, we reported that L-theanine treatment increased ATP production and improved mitochondrial morphology to extend the lifespan of UVC-exposed nematodes. Mechanistic investigations showed that L-theanine treatment enhanced the removal of mtDNA damage and extended lifespan by activating autophagy, mitophagy, mitochondrial dynamics, and mitochondrial unfolded protein response (UPRmt) in UVC-exposed nematodes. In addition, L-theanine treatment also upregulated the expression of genes related to mitochondrial energy metabolism in UVC-exposed nematodes. Our study provides a theoretical basis for the possibility that tea drinking may prevent mitochondrial-related diseases.","journal":"Molecules","year":2024,"id":442581,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9534,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1256328,"name":"Guijie Chen","orcid":"0000-0002-6870-5360","position":1,"is_corresponding":false},{"id":1256821,"name":"Tingting Gai","orcid":null,"position":2,"is_corresponding":false},{"id":1146322,"name":"Xiuhong Zhou","orcid":null,"position":3,"is_corresponding":false},{"id":1256329,"name":"Jinchi Zhu","orcid":"0009-0004-3213-9864","position":4,"is_corresponding":false},{"id":1256822,"name":"Ruiyi Wang","orcid":null,"position":5,"is_corresponding":false},{"id":1223989,"name":"Xuemei Wang","orcid":"0000-0001-6882-7774","position":6,"is_corresponding":false},{"id":918327,"name":"Yujie Guo","orcid":"0000-0002-0307-9266","position":7,"is_corresponding":false},{"id":401459,"name":"Yun Wang","orcid":"0000-0002-4905-6270","position":8,"is_corresponding":false},{"id":1145985,"name":"Zhongwen Xie","orcid":"0000-0002-3080-4881","position":9,"is_corresponding":false},{"id":1145981,"name":"Liangwen Chen","orcid":"0000-0001-6455-0368","position":0,"is_corresponding":true}],"reference_count":59,"raw_metadata":null,"created_at":"2026-07-19T02:01:20.107161Z","pmid":"38893565","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}