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The present review provides a critical update of high-throughput functional metabolomics techniques and diverse applications, and recommends the use of mass spectrometry-based metabolomics for discovering small-molecule metabolite signatures that provide valuable insights into metabolic targets. We also recommend using mass spectrometry-based metabolomics as a powerful tool for identifying and understanding metabolic patterns, metabolic targets and for efficacy evaluation of herbal medicine.</jats:p>","journal":"Molecules","year":2024,"id":599480,"datarank":0.6681520944380261,"base_score":4.454347296253507,"endowment":4.454347296253507,"self_citation_contribution":0.6681520944380261,"citation_network_contribution":0.0,"self_endowment_contribution":0.6681520944380261,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":85,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1197903,"name":"Qianqian Tian","orcid":"0000-0001-7222-0246","position":1,"is_corresponding":false},{"id":1536367,"name":"Sifan Guo","orcid":null,"position":2,"is_corresponding":false},{"id":1536368,"name":"Dandan Xie","orcid":null,"position":3,"is_corresponding":false},{"id":33713,"name":"Ying Cai","orcid":"0000-0001-8766-6005","position":4,"is_corresponding":false},{"id":638777,"name":"Zhibo Wang","orcid":"0009-0000-1152-6591","position":5,"is_corresponding":false},{"id":1212873,"name":"Hang Chu","orcid":null,"position":6,"is_corresponding":false},{"id":516160,"name":"Shi Qiu","orcid":"0000-0003-4870-0236","position":7,"is_corresponding":false},{"id":1536369,"name":"Songqi Tang","orcid":"0000-0001-8314-4613","position":8,"is_corresponding":false},{"id":1038040,"name":"Aihua Zhang","orcid":"0000-0002-3784-4472","position":9,"is_corresponding":false},{"id":1536366,"name":"Chunsheng Lin","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Metabolomics for Clinical Biomarker Discovery and Therapeutic Target Identification","abstract":"<jats:p>As links between genotype and phenotype, small-molecule metabolites are attractive biomarkers for disease diagnosis, prognosis, classification, drug screening and treatment, insight into understanding disease pathology and identifying potential targets. 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