{"doi":"10.3390/molecules29051113","title":"Characterization of the Sideritis scardica Extract SidTea+TM and Its Effect on Physiological Profile, Metabolic Health and Redox Biomarkers in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Study","abstract":"<jats:p>This study aimed to characterize a Sideritis scardica extract (SidTea+TM) and investigate its effect on the physiological profile, metabolic health and redox status in healthy individuals. The chemical profile and antioxidant potential of the SidTea+TM extract were evaluated by UPLC-HRMS analysis and in vitro cell-free methods. Twenty-eight healthy adults participated in this randomized, double-blind, placebo-controlled study. Participants consumed 1500 mg/day of SidTea+TM or a placebo for 4 weeks. At baseline and post-supplementation, participants were assessed for their anthropometric and physiological profile and provided a resting blood sample. SidTea+TM decreased (p &lt; 0.05) systolic blood pressure (−10.8 mmHg), mean arterial pressure (−4.5 mmHg), resting heart rate (−3.1 bpm) and handgrip strength of the non-dominant limb (−0.8 kg) whereas the placebo decreased (p &lt; 0.05) handgrip strength of the dominant (−5.8 kg) and non-dominant (−3.2 kg) limb. SidTea+TM also resulted in an increase (p &lt; 0.05) in estimated VO2max (+1.1 mL/kg/min) and a reduction (p &lt; 0.05) in γ-GT and SGPT enzymatic activity in serum (−3.7 and −3.3 U/L, respectively). Finally, SidTea+TM increased (p &lt; 0.001) total antioxidant capacity and decreased (p &lt; 0.05) lipid peroxidation levels in plasma. These results indicate that SidTea+TM is a potent and safe to use antioxidant that can elicit positive changes in indices of blood pressure, cardiorespiratory capacity, liver metabolism, and redox status in healthy adults over a 4-week supplementation period.</jats:p>","journal":"Molecules","year":2024,"id":645009,"datarank":0.32958368660043297,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.0,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1679277,"name":"Konstantinos Kouloridas","orcid":null,"position":1,"is_corresponding":false},{"id":1679278,"name":"Anastasia Rosvoglou","orcid":"0000-0001-5243-4378","position":2,"is_corresponding":false},{"id":1679279,"name":"Athanasios Gatsas","orcid":"0000-0002-6219-6745","position":3,"is_corresponding":false},{"id":1679280,"name":"Kalliopi Georgakouli","orcid":"0000-0001-5545-9271","position":4,"is_corresponding":false},{"id":1679281,"name":"Chariklia K. 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Participants consumed 1500 mg/day of SidTea+TM or a placebo for 4 weeks. At baseline and post-supplementation, participants were assessed for their anthropometric and physiological profile and provided a resting blood sample. SidTea+TM decreased (p &lt; 0.05) systolic blood pressure (−10.8 mmHg), mean arterial pressure (−4.5 mmHg), resting heart rate (−3.1 bpm) and handgrip strength of the non-dominant limb (−0.8 kg) whereas the placebo decreased (p &lt; 0.05) handgrip strength of the dominant (−5.8 kg) and non-dominant (−3.2 kg) limb. SidTea+TM also resulted in an increase (p &lt; 0.05) in estimated VO2max (+1.1 mL/kg/min) and a reduction (p &lt; 0.05) in γ-GT and SGPT enzymatic activity in serum (−3.7 and −3.3 U/L, respectively). Finally, SidTea+TM increased (p &lt; 0.001) total antioxidant capacity and decreased (p &lt; 0.05) lipid peroxidation levels in plasma. 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