{"doi":"10.3390/molecules27123809","title":"Design and Synthesis of C-1 Methoxycarbonyl Derivative of Narciclasine and Its Biological Activity","abstract":"A 15-step chemoenzymatic total synthesis of C-1 methoxycarbonyl narciclasine (10) was accomplished. The synthesis began with the toluene dioxygenase-mediated dihydroxylation of ortho-dibromobenzene to provide the corresponding cis-dihydrodiol (12) as a single enantiomer. Further key steps included a nitroso Diels–Alder reaction and an intramolecular Heck cyclization. The C-1 homolog 10 was tested and evaluated for antiproliferative activity against natural narciclasine (1) as the positive control. Experimental and spectral data are reported for all novel compounds.","journal":"Molecules","year":2022,"id":295440,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9405,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":770951,"name":"Korey Bedard","orcid":null,"position":1,"is_corresponding":false},{"id":974005,"name":"Mitchell Smith","orcid":"0000-0002-9299-9573","position":2,"is_corresponding":false},{"id":709133,"name":"Liqin Du","orcid":"0000-0002-7097-5861","position":3,"is_corresponding":false},{"id":526597,"name":"Alexander Kornienko","orcid":"0000-0003-2041-7367","position":4,"is_corresponding":false},{"id":770363,"name":"Tomáš Hudlický","orcid":"0000-0003-3239-6815","position":5,"is_corresponding":false},{"id":981740,"name":"Lihi Habaz","orcid":null,"position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":null,"created_at":"2026-07-19T00:31:08.861377Z","pmid":"35744934","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}