{"doi":"10.3390/molecules27113454","title":"Biphenyl Ether Analogs Containing Pomalidomide as Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction","abstract":"New biphenyl-based chimeric compounds containing pomalidomide were developed and evaluated for their activity to inhibit and degrade the programmed cell death-1/programmed cell death- ligand 1 (PD-1/PD-L1) complex. Most of the compounds displayed excellent inhibitory activity against PD-1/PD-L1, as assessed by the homogenous time-resolved fluorescence (HTRF) binding assay. Among them, compound 3 is one of the best with an IC50 value of 60 nM. Using an ex vivo PD-1/PD-L1 blockade cell line bioassay that expresses human PD-1 and PD-L1, we show that compounds 4 and 5 significantly restore the repressed immunity in this co-culture model. Western blot data, however, demonstrated that these anti-PD-L1/pomalidomide chimeras could not reduce the protein levels of PD-L1.","journal":"Molecules","year":2022,"id":285019,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9511,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":963191,"name":"Louis Gadina","orcid":"0000-0002-4090-0789","position":1,"is_corresponding":false},{"id":350632,"name":"Ewa Surmiak","orcid":"0000-0002-4103-4675","position":2,"is_corresponding":false},{"id":599638,"name":"Zefeng Wang","orcid":"0000-0002-5724-444X","position":3,"is_corresponding":false},{"id":463375,"name":"Bidong Zhang","orcid":"0000-0001-9958-3565","position":4,"is_corresponding":false},{"id":420461,"name":"Roberto Butera","orcid":"0000-0001-8978-9893","position":5,"is_corresponding":false},{"id":305446,"name":"Tryfon Zarganes‐Tzitzikas","orcid":"0000-0001-7323-8587","position":6,"is_corresponding":false},{"id":963192,"name":"Ismael Rodríguez","orcid":"0000-0001-9722-610X","position":7,"is_corresponding":false},{"id":640234,"name":"Justyna Kocik-Krol","orcid":"0000-0002-3779-3118","position":8,"is_corresponding":false},{"id":640233,"name":"Katarzyna Magiera‐Mularz","orcid":"0000-0002-4826-6380","position":9,"is_corresponding":false},{"id":350635,"name":"Łukasz Skalniak","orcid":"0000-0002-6707-6697","position":10,"is_corresponding":false},{"id":230785,"name":"Alexander Dömlingꝉ","orcid":"0000-0002-9923-8873","position":11,"is_corresponding":false},{"id":350636,"name":"Tad A. Holak","orcid":"0000-0001-9369-6024","position":12,"is_corresponding":false},{"id":305445,"name":"Shabnam Shaabani","orcid":"0000-0001-5546-7140","position":0,"is_corresponding":true}],"reference_count":37,"raw_metadata":null,"created_at":"2026-07-19T00:29:40.826853Z","pmid":"35684392","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}