{"doi":"10.3390/molecules27092615","title":"Boron Chemicals in Drug Discovery and Development: Synthesis and Medicinal Perspective","abstract":"A standard goal of medicinal chemists has been to discover efficient and potent drug candidates with specific enzyme-inhibitor abilities. In this regard, boron-based bioactive compounds have provided amphiphilic properties to facilitate interaction with protein targets. Indeed, the spectrum of boron-based entities as drug candidates against many diseases has grown tremendously since the first clinically tested boron-based drug, Velcade. In this review, we collectively represent the current boron-containing drug candidates, boron-containing retinoids, benzoxaboroles, aminoboronic acid, carboranes, and BODIPY, for the treatment of different human diseases.In addition, we also describe the synthesis, key structure-activity relationship, and associated biological activities, such as antimicrobial, antituberculosis, antitumor, antiparasitic, antiprotozoal, anti-inflammatory, antifolate, antidepressant, antiallergic, anesthetic, and anti-Alzheimer's agents, as well as proteasome and lipogenic inhibitors. This compilation could be very useful in the exploration of novel boron-derived compounds against different diseases, with promising efficacy and lesser side effects.","journal":"Molecules","year":2022,"id":233263,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":136,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9507,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":846109,"name":"Nitesh Kumar Nandwana","orcid":"0000-0003-1203-7006","position":1,"is_corresponding":false},{"id":846110,"name":"Sasmita Das","orcid":"0000-0003-2867-2266","position":2,"is_corresponding":false},{"id":847131,"name":"Varsha Nandwana","orcid":null,"position":3,"is_corresponding":false},{"id":846111,"name":"Mohd Adil Shareef","orcid":"0000-0003-4422-9109","position":4,"is_corresponding":false},{"id":847132,"name":"Yogarupa Das","orcid":null,"position":5,"is_corresponding":false},{"id":518948,"name":"Mariko Saito","orcid":"0000-0001-9383-4458","position":6,"is_corresponding":false},{"id":320665,"name":"Louis M. Weiss","orcid":"0000-0002-0357-7396","position":7,"is_corresponding":false},{"id":638208,"name":"Frankis Almaguel","orcid":"0009-0001-0404-4129","position":8,"is_corresponding":false},{"id":846112,"name":"Narayan S. Hosmane","orcid":"0000-0002-6421-7546","position":9,"is_corresponding":false},{"id":109233,"name":"Todd Evans","orcid":"0000-0002-7148-9849","position":10,"is_corresponding":false},{"id":499895,"name":"Bhaskar C. Das","orcid":"0000-0002-5837-027X","position":0,"is_corresponding":true}],"reference_count":130,"raw_metadata":null,"created_at":"2026-07-19T00:21:25.223756Z","pmid":"35565972","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}