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The ELISA and RT-qPCR assay findings indicated that GnRb1 suppressed the expression level of pro-inflammatory molecules (TNF-α, IL-1β and IL-6) and boosted the level of anti-inflammatory (IL-10) cytokine. Furthermore, the molecular study suggested that GnRb1 attenuated TLR4-mediated NF-κB signaling. The results demonstrated the therapeutic efficacy of GnRb1 in the mouse model of LPS-triggered endometritis via the inhibition of the TLR4-associated NF-κB pathway. Taken together, this study provides a baseline for the protective effect of GnRb1 to treat endometritis in both humans and animals.</jats:p>","journal":"Molecules","year":2021,"id":667788,"datarank":0.47032413238937254,"base_score":3.1354942159291497,"endowment":3.1354942159291497,"self_citation_contribution":0.47032413238937254,"citation_network_contribution":0.0,"self_endowment_contribution":0.47032413238937254,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1743839,"name":"Irfan Shaukat","orcid":null,"position":1,"is_corresponding":false},{"id":1743840,"name":"Shahid Ali Rajput","orcid":null,"position":2,"is_corresponding":false},{"id":1743841,"name":"Rizwan Shukat","orcid":null,"position":3,"is_corresponding":false},{"id":1743842,"name":"Sana Hanif","orcid":null,"position":4,"is_corresponding":false},{"id":1743843,"name":"Imran Shaukat","orcid":null,"position":5,"is_corresponding":false},{"id":56338,"name":"Xinxin Zhang","orcid":"0000-0002-0598-6425","position":6,"is_corresponding":false},{"id":1006790,"name":"Chao Chen","orcid":"0000-0002-7939-6241","position":7,"is_corresponding":false},{"id":1743844,"name":"Xuyang Sun","orcid":null,"position":8,"is_corresponding":false},{"id":1743845,"name":"Tingzhu Ye","orcid":null,"position":9,"is_corresponding":false},{"id":1743846,"name":"Kaifeng Niu","orcid":null,"position":10,"is_corresponding":false},{"id":1743847,"name":"Zhiqiu Yao","orcid":null,"position":11,"is_corresponding":false},{"id":1584649,"name":"Shadab Shaukat","orcid":null,"position":12,"is_corresponding":false},{"id":1743848,"name":"Muhammad Safdar","orcid":null,"position":13,"is_corresponding":false},{"id":1236715,"name":"Mohamed Abdelrahman","orcid":"0000-0001-5247-8370","position":14,"is_corresponding":false},{"id":1743849,"name":"Umair Riaz","orcid":null,"position":15,"is_corresponding":false},{"id":1386804,"name":"Junwei Zhao","orcid":"0000-0003-1250-2756","position":16,"is_corresponding":false},{"id":31754,"name":"Xiaoying Gu","orcid":null,"position":17,"is_corresponding":false},{"id":91153,"name":"Liguo Yang","orcid":"0000-0002-0990-8694","position":18,"is_corresponding":false},{"id":1743838,"name":"Aftab Shaukat","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Ginsenoside Rb1 Mitigates Escherichia coli Lipopolysaccharide-Induced Endometritis through TLR4-Mediated NF-κB Pathway","abstract":"<jats:p>Endometritis is the inflammatory response of the endometrial lining of the uterus and is associated with low conception rates, early embryonic mortality, and prolonged inter-calving intervals, and thus poses huge economic losses to the dairy industry worldwide. 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