{"doi":"10.3390/molecules26196076","title":"Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity","abstract":"<jats:p>Probiotics are beneficial active microorganisms that colonize the human intestines and change the composition of the flora in particular parts of the host. Recently, the use of probiotics to regulate intestinal flora to improve host immunity has received widespread attention. Recent evidence has shown that probiotics play significant roles in gut microbiota composition, which can inhibit the colonization of pathogenic bacteria in the intestine, help the host build a healthy intestinal mucosa protective layer, and enhance the host immune system. Based on the close relationship between the gut microbiota and human immunity, it has become an extremely effective way to improve human immunity by regulating the gut microbiome with probiotics. In this review, we discussed the influence of probiotics on the gut microbiota and human immunity, and the relationship between immunity, probiotics, gut microbiota, and life quality. We further emphasized the regulation of gut microflora through probiotics, thereby enhancing human immunity and improving people’s lives.</jats:p>","journal":"Molecules","year":2021,"id":602661,"datarank":0.9363334898182749,"base_score":6.2422232654551655,"endowment":6.2422232654551655,"self_citation_contribution":0.9363334898182749,"citation_network_contribution":0.0,"self_endowment_contribution":0.9363334898182749,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":513,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":350278,"name":"Peng Zhang","orcid":"0009-0004-7146-1805","position":1,"is_corresponding":false},{"id":237871,"name":"Xin Zhang","orcid":"0000-0001-9751-7054","position":2,"is_corresponding":false},{"id":1545738,"name":"Xinzhou Wang","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity","abstract":"<jats:p>Probiotics are beneficial active microorganisms that colonize the human intestines and change the composition of the flora in particular parts of the host. Recently, the use of probiotics to regulate intestinal flora to improve host immunity has received widespread attention. Recent evidence has shown that probiotics play significant roles in gut microbiota composition, which can inhibit the colonization of pathogenic bacteria in the intestine, help the host build a healthy intestinal mucosa protective layer, and enhance the host immune system. Based on the close relationship between the gut microbiota and human immunity, it has become an extremely effective way to improve human immunity by regulating the gut microbiome with probiotics. In this review, we discussed the influence of probiotics on the gut microbiota and human immunity, and the relationship between immunity, probiotics, gut microbiota, and life quality. We further emphasized the regulation of gut microflora through probiotics, thereby enhancing human immunity and improving people’s lives.</jats:p>","is_dataset_classified":null,"base_score":6.2422232654551655,"endowment":6.2422232654551655,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34641619","pmcid":"PMC8512487","openalex_id":"https://openalex.org/W3204396902","authors":[],"funders":[{"funder_name":"the Key Research and development program of Zhejiang Province","grant_id":"2018C02023","title":null}],"total_grants":1,"fwci":22.2855,"citation_percentile":0.99785055,"influential_citations":0,"citation_trend":[{"year":2022,"count":35},{"year":2023,"count":76},{"year":2024,"count":176},{"year":2025,"count":170},{"year":2026,"count":56}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.mdpi.com/1420-3049/26/19/6076/pdf?version=1633768599","host_type":"journal"},{"url":"https://www.mdpi.com/1420-3049/26/19/6076/pdf?version=1633768599","host_type":"publisher"},{"url":"https://www.mdpi.com/1420-3049/26/19/6076/pdf","host_type":"publisher"},{"url":"https://doi.org/10.3390/molecules26196076","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/34641619","host_type":"repository"},{"url":"https://doaj.org/article/1e38c322f02c458286fa9dfb6b3adabf","host_type":"repository"},{"url":"https://dx.doi.org/10.3390/molecules26196076","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8512487","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC8512487","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC8512487?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Gut microbiota and health","Probiotics and Fermented Foods","Clostridium difficile and Clostridium perfringens research","Bacteria","Gastrointestinal Microbiome","Humans","Immune System","Probiotics"],"mesh_terms":["Gastrointestinal Microbiome","Bacteria","Humans","Immune System","Probiotics"],"keywords":["Immunity","Gut flora","Immune system","Biology","Mucosal immunity","Flora (microbiology)","Microbiome","Colonisation resistance","Host (biology)","Immunology","Human microbiome","Microbiology","Colonization","Bacteria","Bioinformatics","Ecology","Probiotics","Gut Microbiota"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Responsible consumption and production"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T19:57:28.474427Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}