{"doi":"10.3390/molecules26164958","title":"Polymeric Nanoparticles Active against Dual-Species Bacterial Biofilms","abstract":"Biofilm infections are a global public health threat, necessitating new treatment strategies. Biofilm formation also contributes to the development and spread of multidrug-resistant (MDR) bacterial strains. Biofilm-associated chronic infections typically involve colonization by more than one bacterial species. The co-existence of multiple species of bacteria in biofilms exacerbates therapeutic challenges and can render traditional antibiotics ineffective. Polymeric nanoparticles offer alternative antimicrobial approaches to antibiotics, owing to their tunable physico-chemical properties. Here, we report the efficacy of poly(oxanorborneneimide) (PONI)-based antimicrobial polymeric nanoparticles (PNPs) against multi-species bacterial biofilms. PNPs showed good dual-species biofilm penetration profiles as confirmed by confocal laser scanning microscopy. Broad-spectrum antimicrobial activity was observed, with reduction in both bacterial viability and overall biofilm mass. Further, PNPs displayed minimal fibroblast toxicity and high antimicrobial activity in an in vitro co-culture model comprising fibroblast cells and dual-species biofilms of Escherichia coli and Pseudomonas aeruginosa. This study highlights a potential clinical application of the presented polymeric platform.","journal":"Molecules","year":2021,"id":172789,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9578,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":291828,"name":"Jungmi Park","orcid":"0000-0002-9177-4559","position":1,"is_corresponding":false},{"id":262468,"name":"Cheng‐Hsuan Li","orcid":"0000-0001-9707-1929","position":2,"is_corresponding":false},{"id":426193,"name":"Aritra Nath Chattopadhyay","orcid":"0000-0001-8658-6919","position":3,"is_corresponding":false},{"id":668197,"name":"Ahmed Nabawy","orcid":"0000-0001-6505-4606","position":4,"is_corresponding":false},{"id":290386,"name":"Ryan F. Landis","orcid":null,"position":5,"is_corresponding":false},{"id":480726,"name":"Akash Gupta","orcid":"0000-0001-5614-2313","position":6,"is_corresponding":false},{"id":619595,"name":"Suzannah M. Schmidt-Malan","orcid":null,"position":7,"is_corresponding":false},{"id":232756,"name":"Robin Patel","orcid":"0000-0001-6344-4141","position":8,"is_corresponding":false},{"id":232161,"name":"Vincent M. Rotello","orcid":"0000-0002-5184-5439","position":9,"is_corresponding":false},{"id":262471,"name":"Jessa Marie Makabenta","orcid":"0000-0002-2062-7914","position":0,"is_corresponding":true}],"reference_count":33,"raw_metadata":null,"created_at":"2026-07-18T23:46:41.424716Z","pmid":"34443542","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}