{"doi":"10.3390/molecules26082182","title":"Design, Synthesis, and Validation of a Novel [11C]Promethazine PET Probe for Imaging Abeta Using Autoradiography","abstract":"Promethazine, an antihistamine drug used in the clinical treatment of nausea, has been demonstrated the ability to bind Abeta in a transgenic mouse model of Alzheimer’s disease. However, so far, all of the studies were performed in vitro using extracted tissues. In this work, we report the design and synthesis of a novel [11C]promethazine PET radioligand for future in vivo studies. The [11C]promethazine was isolated by RP-HPLC with radiochemical purity >95% and molar activity of 48 TBq/mmol. The specificity of the probe was demonstrated using human hippocampal tissues via autoradiography.","journal":"Molecules","year":2021,"id":207395,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9538,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":793518,"name":"Mariam I. Boules","orcid":null,"position":1,"is_corresponding":false},{"id":776520,"name":"William J. Behof","orcid":null,"position":2,"is_corresponding":false},{"id":776521,"name":"Justin R. Haynes","orcid":null,"position":3,"is_corresponding":false},{"id":793519,"name":"Dmitry S. Koktysh","orcid":null,"position":4,"is_corresponding":false},{"id":775885,"name":"Adam J. Rosenberg","orcid":"0000-0003-2459-7043","position":5,"is_corresponding":false},{"id":479401,"name":"Mohammed Noor Tantawy","orcid":"0000-0001-5975-7540","position":6,"is_corresponding":false},{"id":747254,"name":"Wellington Pham","orcid":"0000-0002-8408-7611","position":7,"is_corresponding":false},{"id":747766,"name":"Clayton A. Whitmore","orcid":null,"position":0,"is_corresponding":true}],"reference_count":44,"raw_metadata":null,"created_at":"2026-07-18T23:51:49.715594Z","pmid":"33920113","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}