{"doi":"10.3390/molecules26051493","title":"Synthesis and Antiviral Evaluation of (1,4-Disubstituted-1,2,3-Triazol)-(E)-2-Methyl-but-2-Enyl Nucleoside Phosphonate Prodrugs","abstract":"A series of hitherto unknown (1,4-disubstituted-1,2,3-triazol)-(E)-2-methyl-but-2-enyl nucleosides phosphonate prodrugs bearing 4-substituted-1,2,3-triazoles were prepared in a straight approach through an olefin acyclic cross metathesis as the key synthetic step. All novel compounds were evaluated for their antiviral activities against HBV, HIV and SARS-CoV-2. Among these molecules, only compound 15j, a hexadecyloxypropyl (HDP)/(isopropyloxycarbonyl-oxymethyl)-ester (POC) prodrug, showed activity against HBV in Huh7 cell cultures with 62% inhibition at 10 μM, without significant cytotoxicity (IC50 = 66.4 μM in HepG2 cells, IC50 = 43.1 μM in HepG2 cells) at 10 μM.","journal":"Molecules","year":2021,"id":199841,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9515,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":575807,"name":"Vincent Roy","orcid":"0000-0002-3506-4384","position":1,"is_corresponding":false},{"id":776863,"name":"Julien Marlet","orcid":"0000-0002-8645-8703","position":2,"is_corresponding":false},{"id":777555,"name":"Catherine Gaudy‐Graffin","orcid":null,"position":3,"is_corresponding":false},{"id":777556,"name":"Denys Brand","orcid":null,"position":4,"is_corresponding":false},{"id":776864,"name":"Cécile Baronti","orcid":"0000-0002-2319-9484","position":5,"is_corresponding":false},{"id":235137,"name":"Franck Touret","orcid":"0000-0002-4734-2249","position":6,"is_corresponding":false},{"id":235143,"name":"Bruno Coutard","orcid":"0000-0002-2859-7123","position":7,"is_corresponding":false},{"id":315999,"name":"Tamara R. McBrayer","orcid":null,"position":8,"is_corresponding":false},{"id":228075,"name":"Raymond F. Schinazi","orcid":"0000-0002-6688-3614","position":9,"is_corresponding":false},{"id":776865,"name":"Luigi A. Agrofoglio","orcid":"0000-0002-6083-0810","position":10,"is_corresponding":false},{"id":777554,"name":"Tuniyazi Abuduaini","orcid":null,"position":0,"is_corresponding":true}],"reference_count":28,"raw_metadata":null,"created_at":"2026-07-18T23:50:44.479665Z","pmid":"33803417","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}