{"doi":"10.3390/molecules25122866","title":"Role of Lipid-Based and Polymer-Based Non-Viral Vectors in Nucleic Acid Delivery for Next-Generation Gene Therapy","abstract":"The field of gene therapy has experienced an insurgence of attention for its widespread ability to regulate gene expression by targeting genomic DNA, messenger RNA, microRNA, and short-interfering RNA for treating malignant and non-malignant disorders. Numerous nucleic acid analogs have been developed to target coding or non-coding sequences of the human genome for gene regulation. However, broader clinical applications of nucleic acid analogs have been limited due to their poor cell or organ-specific delivery. To resolve these issues, non-viral vectors based on nanoparticles, liposomes, and polyplexes have been developed to date. This review is centered on non-viral vectors mainly comprising of cationic lipids and polymers for nucleic acid-based delivery for numerous gene therapy-based applications.","journal":"Molecules","year":2020,"id":50469,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":192,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9561,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":248945,"name":"Akaash Waghmode","orcid":null,"position":1,"is_corresponding":false},{"id":248946,"name":"Alexander Kapphahn","orcid":null,"position":2,"is_corresponding":false},{"id":226324,"name":"Karishma Dhuri","orcid":"0000-0001-9138-8298","position":3,"is_corresponding":false},{"id":226327,"name":"Anisha Gupta","orcid":"0000-0002-0276-9169","position":4,"is_corresponding":false},{"id":226329,"name":"Raman Bahal","orcid":"0000-0002-4514-8004","position":5,"is_corresponding":false},{"id":247993,"name":"Aniket Wahane","orcid":"0000-0001-9352-8370","position":0,"is_corresponding":true}],"reference_count":155,"raw_metadata":null,"created_at":"2026-07-18T20:38:25.860949Z","pmid":"32580326","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}