{"doi":"10.3390/mi11030273","title":"The Influence of Electron Beam Sterilization on In Vivo Degradation of β-TCP/PCL of Different Composite Ratios for Bone Tissue Engineering","abstract":"We evaluated the effect of electron beam (E-beam) sterilization (25 kGy, ISO 11137) on the degradation of β-tricalcium phosphate/polycaprolactone (β-TCP/PCL) composite filaments of various ratios (0:100, 20:80, 40:60, and 60:40 TCP:PCL by mass) in a rat subcutaneous model for 24 weeks. Volumes of the samples before implantation and after explantation were measured using micro-computed tomography (micro-CT). The filament volume changes before sacrifice were also measured using a live micro-CT. In our micro-CT analyses, there was no significant difference in volume change between the E-beam treated groups and non-E-beam treated groups of the same β-TCP to PCL ratios, except for the 0% β-TCP group. However, the average volume reduction differences between the E-beam and non-E-beam groups in the same-ratio samples were 0.76% (0% TCP), 3.30% (20% TCP), 4.65% (40% TCP), and 3.67% (60% TCP). The E-beam samples generally had more volume reduction in all experimental groups. Therefore, E-beam treatment may accelerate degradation. In our live micro-CT analyses, most volume reduction arose in the first four weeks after implantation and slowed between 4 and 20 weeks in all groups. E-beam groups showed greater volume reduction at every time point, which is consistent with the results by micro-CT analysis. Histology results suggest the biocompatibility of TCP/PCL composite filaments.","journal":"Micromachines","year":2020,"id":69643,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.956,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":368942,"name":"Janelle M. Kaneda","orcid":"0000-0002-3299-7496","position":1,"is_corresponding":false},{"id":370260,"name":"Jae-Gon Jang","orcid":null,"position":2,"is_corresponding":false},{"id":368943,"name":"Kumaresan Sakthiabirami","orcid":"0000-0001-7781-705X","position":3,"is_corresponding":false},{"id":368944,"name":"Elaine Lui","orcid":"0000-0001-7967-6596","position":4,"is_corresponding":false},{"id":368945,"name":"Carolyn Kim","orcid":"0000-0001-7355-7107","position":5,"is_corresponding":false},{"id":259298,"name":"Aijun Wang","orcid":"0000-0002-2985-3627","position":6,"is_corresponding":false},{"id":368946,"name":"Sang-Won Park","orcid":"0000-0002-9376-9104","position":7,"is_corresponding":false},{"id":354461,"name":"Yunzhi Yang","orcid":"0000-0002-3891-0574","position":8,"is_corresponding":false},{"id":368941,"name":"Jin Ho Kang","orcid":"0000-0003-0912-8281","position":0,"is_corresponding":true}],"reference_count":53,"raw_metadata":null,"created_at":"2026-07-18T21:42:48.813846Z","pmid":"32155781","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}