{"doi":"10.3390/metabo14040208","title":"Pancreatic Beta Cell Function in Infants Varies by Maternal Weight","abstract":"The Asian Indian Beta Cell function (ABCs) in Infants Study examined the associations of maternal weight on infant pancreatic beta cell function across 7 months postpartum. Pregnant women aged 18–35 years were recruited in Hyderabad, India. Women were classified by first trimester weight as underweight (UW), BMI < 18.5 kg/m2; normal weight (NW), BMI 18.5–22.9 kg/m2; or overweight (OW), BMI 23.0 through <28.5 kg/m2. At age > 7 months, infants had an oral glucose tolerance test (OGTT, 1.75 g glucose/kg bodyweight) following a 3 h fast. Infant blood samples were assayed for C-peptide and glucose. Infant beta cell function (HOMA2-B; disposition index, DI) and insulin resistance (HOMA2-IR) were compared across maternal weight groups. Mothers (UW n = 63; NW n = 43; OW n = 29) had similar age at delivery and second trimester 50 g glucose challenge test results. Cord HOMA2-B values were 51% greater for IUW (83.5, SD 55.2) and 44% greater for IOW (79.9, SD 60.8) vs. INW (55.4, SD 51.5), forming a U-shaped relationship between maternal weight and HOMA2-B. No qualitative differences in HOMA2-IR were found at birth. However, at 7 months postpartum, HOMA2-IR changed most within IUW (−64% median reduction) and changed the least in IOW (−7% median reduction). At seven months postpartum, DI was higher in IUW vs. the other groups (geometric mean IUW 1.9 SD 2.5; INW 1.3 SD 2.6 or vs. IOW mean 1.2 SD 3.7), reflecting a +49% difference in DI. Evidence from this study illustrates adaptations in the pancreatic functional response of infants associated with the maternal nutritional environment.","journal":"Metabolites","year":2024,"id":470798,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9181,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1213767,"name":"Anubrati Dutta","orcid":"0009-0002-2301-9399","position":1,"is_corresponding":false},{"id":1305131,"name":"Yara S. Beyh","orcid":"0000-0002-6588-0753","position":2,"is_corresponding":false},{"id":519592,"name":"Ruby Gupta","orcid":"0000-0002-8487-6004","position":3,"is_corresponding":false},{"id":1305470,"name":"Hari Krishna Noule","orcid":null,"position":4,"is_corresponding":false},{"id":1305471,"name":"Vyakaranam Sapna","orcid":null,"position":5,"is_corresponding":false},{"id":1305472,"name":"K P Deepa","orcid":null,"position":6,"is_corresponding":false},{"id":39202,"name":"Aryeh D. Stein","orcid":"0000-0003-1138-6458","position":7,"is_corresponding":false},{"id":245134,"name":"K.M. Venkat Narayan","orcid":"0000-0001-8621-5405","position":8,"is_corresponding":false},{"id":23230,"name":"Dorairaj Prabhakaran","orcid":"0000-0002-3172-834X","position":9,"is_corresponding":false},{"id":1305473,"name":"Kalpana Basany","orcid":null,"position":10,"is_corresponding":false},{"id":1211233,"name":"Poornima Prabhakaran","orcid":"0000-0003-3134-7026","position":11,"is_corresponding":false},{"id":492743,"name":"Lisa R. Staimez","orcid":"0000-0002-2818-1187","position":0,"is_corresponding":true}],"reference_count":43,"raw_metadata":null,"created_at":"2026-07-19T02:05:40.740958Z","pmid":"38668336","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}