{"doi":"10.3390/metabo12070616","title":"The Influence of Orthopedic Surgery on Circulating Metabolite Levels, and their Associations with the Incidence of Postoperative Delirium","abstract":"The mechanisms underlying the occurrence of postoperative delirium development are unclear and measurement of plasma metabolites may improve understanding of its causes. Participants (n = 54) matched for age and gender were sampled from an observational cohort study investigating postoperative delirium. Participants were ≥65 years without a diagnosis of dementia and presented for primary elective hip or knee arthroplasty. Plasma samples collected pre- and postoperatively were grouped as either control (n = 26, aged: 75.8 ± 5.2) or delirium (n = 28, aged: 76.2 ± 5.7). Widespread changes in plasma metabolite levels occurred following surgery. The only metabolites significantly differing between corresponding control and delirium samples were ornithine and spermine. In delirium cases, ornithine was 17.6% higher preoperatively, and spermine was 12.0% higher postoperatively. Changes were not associated with various perioperative factors. In binary logistic regression modeling, these two metabolites did not confer a significantly increased risk of delirium. These findings support the hypothesis that disturbed polyamine metabolism is an underlying factor in delirium that warrants further investigation.","journal":"Metabolites","year":2022,"id":279258,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9264,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":667672,"name":"Xiaobei Pan","orcid":"0000-0002-6526-1338","position":1,"is_corresponding":false},{"id":952332,"name":"Emma Cunningham","orcid":"0000-0002-9912-5174","position":2,"is_corresponding":false},{"id":952836,"name":"Anthony Peter Passmore","orcid":null,"position":3,"is_corresponding":false},{"id":793932,"name":"Bernadette McGuinness","orcid":"0000-0002-7028-5633","position":4,"is_corresponding":false},{"id":81249,"name":"Daniel F. McAuley","orcid":"0000-0002-3283-1947","position":5,"is_corresponding":false},{"id":952333,"name":"David Beverland","orcid":"0000-0002-7951-2927","position":6,"is_corresponding":false},{"id":952334,"name":"Seamus O’Brien","orcid":"0000-0001-8059-247X","position":7,"is_corresponding":false},{"id":952837,"name":"Tim Mawhinney","orcid":null,"position":8,"is_corresponding":false},{"id":447588,"name":"Jonathan M. Schott","orcid":"0000-0003-2059-024X","position":9,"is_corresponding":false},{"id":27601,"name":"Henrik Zetterberg","orcid":"0000-0003-3930-4354","position":10,"is_corresponding":false},{"id":667674,"name":"Brian D. Green","orcid":"0000-0003-3331-0032","position":11,"is_corresponding":false},{"id":952331,"name":"Mijin Jung","orcid":"0000-0002-8481-4444","position":0,"is_corresponding":true}],"reference_count":42,"raw_metadata":null,"created_at":"2026-07-19T00:28:51.322666Z","pmid":"35888740","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}