{"doi":"10.3390/metabo11080494","title":"Sensory Circumventricular Organs, Neuroendocrine Control, and Metabolic Regulation","abstract":"<jats:p>The central nervous system is critical in metabolic regulation, and accumulating evidence points to a distributed network of brain regions involved in energy homeostasis. This is accomplished, in part, by integrating peripheral and central metabolic information and subsequently modulating neuroendocrine outputs through the paraventricular and supraoptic nucleus of the hypothalamus. However, these hypothalamic nuclei are generally protected by a blood-brain-barrier limiting their ability to directly sense circulating metabolic signals—pointing to possible involvement of upstream brain nuclei. In this regard, sensory circumventricular organs (CVOs), brain sites traditionally recognized in thirst/fluid and cardiovascular regulation, are emerging as potential sites through which circulating metabolic substances influence neuroendocrine control. The sensory CVOs, including the subfornical organ, organum vasculosum of the lamina terminalis, and area postrema, are located outside the blood-brain-barrier, possess cellular machinery to sense the metabolic interior milieu, and establish complex neural networks to hypothalamic neuroendocrine nuclei. Here, evidence for a potential role of sensory CVO-hypothalamic neuroendocrine networks in energy homeostasis is presented.</jats:p>","journal":"Metabolites","year":2021,"id":18666,"datarank":0.8767814201219292,"base_score":3.6635616461296463,"endowment":3.6635616461296463,"self_citation_contribution":0.5495342469194471,"citation_network_contribution":0.3272471732024821,"self_endowment_contribution":0.5495342469194471,"citer_contribution":0.3272471732024821,"corpus_percentile":null,"corpus_rank":null,"citation_count":38,"citer_count":33,"citers_with_citation_signal":25,"citers_with_endowment":25,"datacite_reuse_total":2,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":128934,"name":"Samantha A. Dow","orcid":"0000-0003-2146-0877","position":1,"is_corresponding":false},{"id":128935,"name":"Colin N. Young","orcid":null,"position":2,"is_corresponding":false},{"id":128933,"name":"Jin Kwon Jeong","orcid":"0000-0002-5261-4915","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":3.6635616461296463,"endowment":3.6635616461296463,"datacite_reuse_total":2,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34436435","pmcid":"PMC8402088","openalex_id":"https://openalex.org/W3184764656","authors":[],"funders":[{"funder_name":"American Heart Association","grant_id":"19CDA34630010","title":null},{"funder_name":"National Institutes of Health","grant_id":"R01HL141393","title":null},{"funder_name":"National Institutes of Health","grant_id":"R01DK117007","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R00 HL116776","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R01HL141393-05","title":"Forebrain-hypothalamic mechanisms in obesity-induced hypertension"},{"funder_name":"National Institutes of Health","grant_id":"5R01DK117007-03","title":"Brain endoplasmic reticulum stress in non-alcoholic fatty liver disease"}],"total_grants":6,"fwci":2.5631,"citation_percentile":0.90224618,"influential_citations":2,"citation_trend":[{"year":2022,"count":4},{"year":2023,"count":12},{"year":2024,"count":11},{"year":2025,"count":9},{"year":2026,"count":2}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.mdpi.com/2218-1989/11/8/494/pdf?version=1627554334","host_type":"journal"},{"url":"https://www.mdpi.com/2218-1989/11/8/494/pdf?version=1627554334","host_type":"GOLD"},{"url":"https://www.mdpi.com/2218-1989/11/8/494/pdf?version=1627554334","host_type":"publisher"},{"url":"https://www.mdpi.com/2218-1989/11/8/494/pdf","host_type":"publisher"},{"url":"https://doi.org/10.3390/metabo11080494","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/34436435","host_type":"repository"},{"url":"https://doaj.org/article/88fc5c11e22d4b6dbc7b1286c52e2bf2","host_type":"repository"},{"url":"https://dx.doi.org/10.3390/metabo11080494","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8402088","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC8402088","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC8402088?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.3390/metabo11080494","host_type":""}],"fields_of_study":["Regulation of Appetite and Obesity","Adipose Tissue and Metabolism","Birth, Development, and Health","Medicine","Biology","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":[],"keywords":["Subfornical organ","Circumventricular organs","Area postrema","Lamina terminalis","Neuroscience","Hypothalamus","Energy homeostasis","Homeostasis","Biology","Thirst","Central nervous system","Endocrinology","Angiotensin II","Blood pressure","Metabolism","Organum Vasculosum Of The Lamina Terminalis","Review","Microbiology","QR1-502"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Affordable and clean energy"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.24223899.v1","title":"Additional file 2 of Unbiased multitissue transcriptomic analysis reveals complex neuroendocrine regulatory networks mediated by spinal cord injury-induced immunodeficiency","publisher":"figshare","resource_type":"Image"},{"doi":"10.6084/m9.figshare.24223899","title":"Additional file 2 of Unbiased multitissue transcriptomic analysis reveals complex neuroendocrine regulatory networks mediated by spinal cord injury-induced immunodeficiency","publisher":"figshare","resource_type":"Image"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-03T23:04:43.958390Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}