{"doi":"10.3390/md21120609","title":"Therapeutic Potential of Marine-Derived Cyclic Peptides as Antiparasitic Agents","abstract":"<jats:p>Parasitic diseases still compromise human health. Some of the currently available therapeutic drugs have limitations considering their adverse effects, questionable efficacy, and long treatment, which have encouraged drug resistance. There is an urgent need to find new, safe, effective, and affordable antiparasitic drugs. Marine-derived cyclic peptides have been increasingly screened as candidates for developing new drugs. Therefore, in this review, a systematic analysis of the scientific literature was performed and 25 marine-derived cyclic peptides with antiparasitic activity (1–25) were found. Antimalarial activity is the most reported (51%), followed by antileishmanial (27%) and antitrypanosomal (20%) activities. Some compounds showed promising antiparasitic activity at the nM scale, being active against various parasites. The mechanisms of action and targets for some of the compounds have been investigated, revealing different strategies against parasites.</jats:p>","journal":"Marine Drugs","year":2023,"id":636138,"datarank":0.4493598410330987,"base_score":2.995732273553991,"endowment":2.995732273553991,"self_citation_contribution":0.4493598410330987,"citation_network_contribution":0.0,"self_endowment_contribution":0.4493598410330987,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":19,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1650811,"name":"Lia Costa","orcid":"0000-0003-0780-7408","position":1,"is_corresponding":false},{"id":1403015,"name":"Eugénia Pinto","orcid":"0000-0003-2948-5809","position":2,"is_corresponding":false},{"id":1435538,"name":"Emı́lia Sousa","orcid":"0000-0002-5397-4672","position":3,"is_corresponding":false},{"id":1650812,"name":"Carla Fernandes","orcid":"0000-0003-0940-9163","position":4,"is_corresponding":false},{"id":318269,"name":"Ricardo Ribeiro","orcid":"0000-0003-1591-0499","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Therapeutic Potential of Marine-Derived Cyclic Peptides as Antiparasitic Agents","abstract":"<jats:p>Parasitic diseases still compromise human health. Some of the currently available therapeutic drugs have limitations considering their adverse effects, questionable efficacy, and long treatment, which have encouraged drug resistance. There is an urgent need to find new, safe, effective, and affordable antiparasitic drugs. Marine-derived cyclic peptides have been increasingly screened as candidates for developing new drugs. Therefore, in this review, a systematic analysis of the scientific literature was performed and 25 marine-derived cyclic peptides with antiparasitic activity (1–25) were found. Antimalarial activity is the most reported (51%), followed by antileishmanial (27%) and antitrypanosomal (20%) activities. Some compounds showed promising antiparasitic activity at the nM scale, being active against various parasites. The mechanisms of action and targets for some of the compounds have been investigated, revealing different strategies against parasites.</jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38132930","pmcid":"PMC10745025","openalex_id":null,"authors":[],"funders":[{"funder_name":"FCT—Foundation for Science and Technology","grant_id":"UIDB/04423/2020","title":"Interdisciplinary Centre of Marine and Environmental Research"},{"funder_name":"FCT—Foundation for Science and Technology","grant_id":"UIDP/04423/2020","title":"Interdisciplinary Centre of Marine and Environmental Research"},{"funder_name":"FCT—Foundation for Science and Technology","grant_id":"NORTE-01-0145-FEDER-000040","title":null},{"funder_name":"FCT—Foundation for Science and Technology","grant_id":"PTDC/CTA-AMB/0853/2021","title":"Sustainable antifouling agents: from grape wastes to the sea with the green chemistry leading the way."},{"funder_name":"FCT—Foundation for Science and Technology","grant_id":"EXPL/CTA-AMB/0810/2021","title":"Siderophore efflux pump inhibitors (SEPIs) conjugates: A new concept for environmental problems"},{"funder_name":"Fundação para a Ciência e Tecnologia","grant_id":"UIDB/04423/2020, UIDP/04423/2020, PTDC/CTA-AMB/0853/2021, EXPL/CTA-AMB/0810/2021","title":null}],"total_grants":6,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.mdpi.com/1660-3397/21/12/609/pdf?version=1700898953","host_type":"publisher"},{"url":"https://www.mdpi.com/1660-3397/21/12/609/pdf","host_type":"publisher"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10745025/pdf/marinedrugs-21-00609.pdf","host_type":"repository"},{"url":"https://doaj.org/article/f36ed6e6594b48b49489f902f7a0a8af","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC10745025","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC10745025?pdf=render","host_type":"Europe_PMC"},{"url":"https://doi.org/10.3390/md21120609","host_type":""},{"url":"https://pubmed.ncbi.nlm.nih.gov/38132930","host_type":""},{"url":"http://dx.doi.org/10.3390/md21120609","host_type":""}],"fields_of_study":["0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":["Humans","Parasitic Diseases","Leishmaniasis","Peptides, Cyclic","Antiparasitic Agents","Antiprotozoal Agents"],"keywords":["Malaria","Marine resources","Cyclic peptides","Trypanosomiasis","Leishmaniasis","Antiparasitic Activity","Antiparasitic Agents","QH301-705.5","Antiprotozoal Agents","Review","Peptides, Cyclic","Parasitic Diseases","Humans","Biology (General)"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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