{"doi":"10.3390/livers5030034","title":"Low Hepatic CEACAM1 Tethers Metabolic Dysfunction Steatohepatitis to Atherosclerosis","abstract":"Metabolic dysfunction-associated steatohepatitis (MASH) and atherosclerosis are cardiometabolic twin disorders with shared underlying pathophysiological mechanisms such as insulin resistance and chronic inflammation. This review explores the salient role of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in linking hepatic dysfunction to cardiovascular disease. Findings in mice with genetic modulation of Ceacam1 gene established a critical role for CEACAM1 protein in regulating insulin and lipid metabolism and endothelial integrity and modulating immune response. Loss of CEACAM1 in hepatocytes impairs insulin clearance, causing chronic hyperinsulinemia, a process that ultimately leads to insulin resistance and hepatic and extra-hepatic fat accumulation, which in turn causes inflammatory infiltration. This prompts a paradigm shift that positions impaired hepatic CEACAM1 function as a mechanistic underpinning of the link between insulin resistance, MASH, and atherosclerosis.","journal":"Livers","year":2025,"id":571236,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9576,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1477389,"name":"Sami N. Al Harake","orcid":null,"position":1,"is_corresponding":false},{"id":1266171,"name":"Tya Youssef","orcid":null,"position":2,"is_corresponding":false},{"id":1477063,"name":"Carl E. Risk","orcid":"0009-0003-3994-8157","position":3,"is_corresponding":false},{"id":1477390,"name":"Nabil Helou","orcid":null,"position":4,"is_corresponding":false},{"id":1477391,"name":"Natalie M. Doumet","orcid":null,"position":5,"is_corresponding":false},{"id":1266173,"name":"Karl Aramouni","orcid":null,"position":6,"is_corresponding":false},{"id":854783,"name":"Nadim S. Azar","orcid":"0009-0004-3544-7184","position":7,"is_corresponding":false},{"id":449845,"name":"Sonia M. Najjar","orcid":"0000-0001-6209-8902","position":8,"is_corresponding":false},{"id":449842,"name":"Hilda E. Ghadieh","orcid":"0000-0002-7983-2090","position":9,"is_corresponding":false},{"id":1477388,"name":"Salem Khoury","orcid":null,"position":0,"is_corresponding":true}],"reference_count":310,"raw_metadata":null,"created_at":"2026-07-19T02:57:15.755535Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}