{"doi":"10.3390/life15121871","title":"Multiscale Segmentation-Guided Diffusion Model for CBCT-to-CT Synthesis","abstract":"To improve synthetic CT (sCT) generation from cone-beam CT (CBCT) in radiotherapy, we propose a multiscale segmentation-guided diffusion framework. The proposed model integrates anatomical priors across multiple spatial resolutions through a segmentation mask pyramid and introduces a scale-specific loss function to guide learning at each level. When evaluated on the SynthRAD2023 brain dataset, our model achieves a mean absolute error (MAE) of 61.82 HU, a peak signal-to-noise ratio (PSNR) of 32.05 dB, and a structural similarity index (SSIM) of 0.90, outperforming baseline models. These results suggest that multiscale anatomical guidance can improve the fidelity and anatomical consistency of sCT images, thus facilitating high-quality CBCT-to-CT translation in radiotherapy applications.","journal":"Life","year":2025,"id":584490,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9545,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1278892,"name":"Yi Luo","orcid":"0000-0003-4470-220X","position":1,"is_corresponding":false},{"id":753438,"name":"Hamed Hooshangnejad","orcid":"0000-0002-1953-0568","position":2,"is_corresponding":false},{"id":436547,"name":"Rui Zhang","orcid":"0000-0002-3871-1356","position":3,"is_corresponding":false},{"id":58496,"name":"Xue Feng","orcid":"0000-0002-2181-9889","position":4,"is_corresponding":false},{"id":1054074,"name":"Quan Chen","orcid":"0000-0003-0056-5207","position":5,"is_corresponding":false},{"id":257638,"name":"Wilfred Ngwa","orcid":"0000-0001-8317-6850","position":6,"is_corresponding":false},{"id":407759,"name":"Kai Ding","orcid":"0000-0002-8202-0173","position":7,"is_corresponding":false},{"id":769313,"name":"Yike Guo","orcid":"0000-0002-3075-2161","position":0,"is_corresponding":true}],"reference_count":30,"raw_metadata":null,"created_at":"2026-07-19T02:59:11.978098Z","pmid":"41465810","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}