{"doi":"10.3390/jpm14060645","title":"Effects of NF-κB Inhibitor on Sepsis Depend on the Severity and Phase of the Animal Sepsis Model","abstract":"Hyperinflammation occurs in sepsis, especially in the early phase, and it could have both positive and negative effects on sepsis. Previously, we showed that a new concept of NF-κB inhibitor, exosome-based super-repressor IκBα (Exo-srIκB) delivery, has a beneficial effect on sepsis. Here, we further investigate the therapeutic effects of Exo-srIκB at different severities and phases of sepsis using an animal polymicrobial intra-abdominal infection model. We used a rat model of fecal slurry polymicrobial sepsis. First, we determined the survival effects of Exo-srIκB on sepsis according to the severity. We used two different severities of the animal sepsis model. The severe model had a mortality rate of over 50%. The mild/moderate model had a less than 30% mortality rate. Second, we administered the Exo-srIκB at various time points (1 h, 6 h, and 24 h after fecal slurry administration) to determine the therapeutic effect of Exo-srIκB at different phases of sepsis. Lastly, we determined the effects of the Exo-srIκB on cytokine production, arterial blood gas, electrolyte, and lactate. The survival gain was statistically significant in the severe sepsis model when Exo-srIκB was administered 6 h after sepsis. Interleukin 6 and interleukin-10 were significantly decreased in the kidney when administered with Exo-srIκB. The laboratory data showed that lactate, glucose, and potassium levels were significantly lowered in the NF-κB inhibitor group. In conclusion, Exo-srIκB exhibited a beneficial therapeutic effect when administered 6 h post fecal slurry administration in a severe sepsis model.","journal":"Journal of Personalized Medicine","year":2024,"id":446953,"datarank":0.29188652235829704,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.0,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.954,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1264155,"name":"Jinkun Bae","orcid":"0000-0001-9605-7965","position":1,"is_corresponding":false},{"id":16283,"name":"Jae‐Kwang Yoo","orcid":"0000-0001-9300-2846","position":2,"is_corresponding":false},{"id":1264156,"name":"So‐Hee Ahn","orcid":"0000-0002-5079-545X","position":3,"is_corresponding":false},{"id":760178,"name":"Seon Young Park","orcid":null,"position":4,"is_corresponding":false},{"id":1096871,"name":"Yun-Seok Kim","orcid":"0000-0003-4186-7877","position":5,"is_corresponding":false},{"id":1264576,"name":"Min Ji Lee","orcid":null,"position":6,"is_corresponding":false},{"id":1264577,"name":"Seon Young Moon","orcid":null,"position":7,"is_corresponding":false},{"id":1264157,"name":"Tae Nyoung Chung","orcid":"0000-0003-3537-4136","position":8,"is_corresponding":false},{"id":643158,"name":"Chulhee Choi","orcid":"0000-0001-5542-9136","position":9,"is_corresponding":false},{"id":1096873,"name":"Kyuseok Kim","orcid":"0000-0002-7991-9428","position":10,"is_corresponding":false},{"id":1096870,"name":"Ye Jin Park","orcid":"0009-0009-1109-2282","position":0,"is_corresponding":true}],"reference_count":20,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:01:54.980444Z","pmid":"38929866","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}