{"doi":"10.3390/jpm13050857","title":"Highly Selective Targeting of Pancreatic Cancer in the Liver with a Near-Infrared Anti-MUC5AC Probe in a PDOX Mouse Model: A Proof-of-Concept Study","abstract":"Accurately identifying metastatic disease is critical to directing the appropriate treatment in pancreatic cancer. Mucin 5AC is overexpressed in pancreatic cancer but absent in normal pancreas tissue. The present proof-of-concept study demonstrates the efficacy of an anti-mucin 5AC antibody conjugated to an IR800 dye (MUC5AC-IR800) to preferentially label a liver metastasis of pancreatic cancer (Panc Met) in a unique patient-derived orthotopic xenograft (PDOX) model. In orthotopic models, the mean tumor to background ratio was 1.787 (SD ± 0.336), and immunohistochemistry confirmed the expression of MUC5AC within tumor cells. MUC5AC-IR800 provides distinct visualization of pancreatic cancer liver metastasis in a PDOX mouse model, demonstrating its potential utility in staging laparoscopy and fluorescence-guided surgery.","journal":"Journal of Personalized Medicine","year":2023,"id":376979,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.953,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":464909,"name":"Kristin E. Cox","orcid":"0000-0001-8621-1869","position":1,"is_corresponding":false},{"id":939372,"name":"Nicholas Neel","orcid":"0000-0003-0225-762X","position":2,"is_corresponding":false},{"id":432271,"name":"Siamak Amirfakhri","orcid":"0000-0002-5534-1043","position":3,"is_corresponding":false},{"id":428098,"name":"Hiroto Nishino","orcid":"0000-0002-7377-9997","position":4,"is_corresponding":false},{"id":303600,"name":"Bryan M. Clary","orcid":null,"position":5,"is_corresponding":false},{"id":228442,"name":"Mojgan Hosseini","orcid":"0000-0002-6708-7126","position":6,"is_corresponding":false},{"id":404644,"name":"Gopalakrishnan Natarajan","orcid":"0000-0001-8813-764X","position":7,"is_corresponding":false},{"id":255899,"name":"Kavita Mallya","orcid":"0000-0001-6562-5827","position":8,"is_corresponding":false},{"id":337360,"name":"Aaron M. Mohs","orcid":"0000-0002-9353-5404","position":9,"is_corresponding":false},{"id":370841,"name":"Robert M. Hoffman","orcid":"0000-0002-0049-0041","position":10,"is_corresponding":false},{"id":106461,"name":"Surinder K. Batra","orcid":"0000-0001-9470-9317","position":11,"is_corresponding":false},{"id":399592,"name":"Michael Bouvet","orcid":"0000-0002-0086-2159","position":12,"is_corresponding":false},{"id":432270,"name":"Michael A. Turner","orcid":"0000-0001-8949-3136","position":0,"is_corresponding":true}],"reference_count":40,"raw_metadata":null,"created_at":"2026-07-19T01:16:32.368674Z","pmid":"37241027","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}