{"doi":"10.3390/jpm11111086","title":"Vaccinated Patients Admitted in ICU with Severe Pneumonia Due to SARS-CoV-2: A Multicenter Pilot Study","abstract":"<jats:p>Background: The aim of this study was to analyze the percentage of patients admitted to the ICU having received the vaccine against COVID-19, to describe the clinical profile of vaccinated patients admitted to the ICU, and to assess the humoral immune response to vaccination. Methods: In this multicenter prospective descriptive cohort study, consecutive critically ill patients with confirmed SARS-CoV-2 pneumonia who received at least one dose of the SARS-CoV-2 vaccine were included. The time of study was from 1 July to 10 August of 2021. Results: Of the 94 consecutive patients from seven Andalusian ICUs admitted during the time of study, 50 (53.2%) received at least one dose of anti SARS-CoV-2 vaccine. No patient was admitted having previously had SARS-CoV-2 infection. The B.1.617.2 (Delta) variant was the most frequently identified, in 80.76% of cases. Patients with a complete vaccination with non-optimal antibody levels were immunocompromised. Fifteen patients were admitted to the ICU with Acute Respiratory Distress Syndrome (ARDS) without having completed their vaccination; the clinical profile was younger and with less comorbidities compared to patients with full vaccination. There were no differences in severity of ARDS. Conclusions: Most of the patients who were admitted to the ICU having received a dose of the vaccine were not optimally vaccinated; fully vaccinated patients who did not obtain optimal serum antibody levels were patients considered immunocompromised.</jats:p>","journal":"Journal of Personalized Medicine","year":2021,"id":632845,"datarank":0.40620753016533157,"base_score":2.70805020110221,"endowment":2.70805020110221,"self_citation_contribution":0.40620753016533157,"citation_network_contribution":0.0,"self_endowment_contribution":0.40620753016533157,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1640525,"name":"Mª Luisa Cantón","orcid":"0000-0003-1024-2954","position":1,"is_corresponding":false},{"id":1024250,"name":"Laura Muñoz","orcid":"0000-0003-3877-125X","position":2,"is_corresponding":false},{"id":1640526,"name":"Isabel Rodriguez Higueras","orcid":null,"position":3,"is_corresponding":false},{"id":1640528,"name":"María Recuerda Núñez","orcid":"0000-0001-8466-9307","position":4,"is_corresponding":false},{"id":1640530,"name":"Julia Tejero Aranguren","orcid":"0000-0002-6303-852X","position":5,"is_corresponding":false},{"id":1640532,"name":"Benito Zaya","orcid":null,"position":6,"is_corresponding":false},{"id":14363,"name":"Carmen Gómez","orcid":"0000-0002-5414-7935","position":7,"is_corresponding":false},{"id":1640538,"name":"Rosario Amaya","orcid":null,"position":8,"is_corresponding":false},{"id":1640541,"name":"Ángela Hurtado Martinez","orcid":null,"position":9,"is_corresponding":false},{"id":1640543,"name":"María del Valle Odero Bernal","orcid":null,"position":10,"is_corresponding":false},{"id":1640546,"name":"Carmen De la Fuente","orcid":null,"position":11,"is_corresponding":false},{"id":1640548,"name":"Juan Carlos Alados","orcid":null,"position":12,"is_corresponding":false},{"id":1640549,"name":"Jose Garnacho-Montero","orcid":null,"position":13,"is_corresponding":false},{"id":1640524,"name":"Ángel Estella","orcid":"0000-0003-0665-557X","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Vaccinated Patients Admitted in ICU with Severe Pneumonia Due to SARS-CoV-2: A Multicenter Pilot Study","abstract":"<jats:p>Background: The aim of this study was to analyze the percentage of patients admitted to the ICU having received the vaccine against COVID-19, to describe the clinical profile of vaccinated patients admitted to the ICU, and to assess the humoral immune response to vaccination. Methods: In this multicenter prospective descriptive cohort study, consecutive critically ill patients with confirmed SARS-CoV-2 pneumonia who received at least one dose of the SARS-CoV-2 vaccine were included. The time of study was from 1 July to 10 August of 2021. Results: Of the 94 consecutive patients from seven Andalusian ICUs admitted during the time of study, 50 (53.2%) received at least one dose of anti SARS-CoV-2 vaccine. No patient was admitted having previously had SARS-CoV-2 infection. The B.1.617.2 (Delta) variant was the most frequently identified, in 80.76% of cases. Patients with a complete vaccination with non-optimal antibody levels were immunocompromised. Fifteen patients were admitted to the ICU with Acute Respiratory Distress Syndrome (ARDS) without having completed their vaccination; the clinical profile was younger and with less comorbidities compared to patients with full vaccination. There were no differences in severity of ARDS. Conclusions: Most of the patients who were admitted to the ICU having received a dose of the vaccine were not optimally vaccinated; fully vaccinated patients who did not obtain optimal serum antibody levels were patients considered immunocompromised.</jats:p>","is_dataset_classified":null,"base_score":2.70805020110221,"endowment":2.70805020110221,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34834437","pmcid":"PMC8625038","openalex_id":"https://openalex.org/W3208000581","authors":[],"funders":[],"total_grants":0,"fwci":0.8054,"citation_percentile":0.75674745,"influential_citations":0,"citation_trend":[{"year":2021,"count":1},{"year":2022,"count":4},{"year":2023,"count":6},{"year":2024,"count":2},{"year":2026,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.mdpi.com/2075-4426/11/11/1086/pdf?version=1635239735","host_type":"journal"},{"url":"https://www.mdpi.com/2075-4426/11/11/1086/pdf?version=1635239735","host_type":"publisher"},{"url":"https://www.mdpi.com/2075-4426/11/11/1086/pdf","host_type":"publisher"},{"url":"https://doi.org/10.3390/jpm11111086","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/34834437","host_type":"repository"},{"url":"https://doaj.org/article/ac691f79160c4104a33718551dc8708e","host_type":"repository"},{"url":"https://dx.doi.org/10.3390/jpm11111086","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8625038","host_type":"repository"},{"url":"http://hdl.handle.net/10498/27309","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC8625038","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC8625038?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["SARS-CoV-2 and COVID-19 Research","COVID-19 Clinical Research Studies","Vaccine Coverage and Hesitancy"],"mesh_terms":[],"keywords":["Medicine","ARDS","Vaccination","Pneumonia","Prospective cohort study","Internal medicine","Pediatrics","Immunology","Lung","Vaccine","ICU","Acute respiratory distress syndrome","Severe pneumonia","Sars-cov-2","Delta Variant Sars-cov-2"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"doi"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T10:26:23.069471Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}