{"doi":"10.3390/jpm11040303","title":"Treatment Efficacy with a Novel Hyaluronic Acid-Based Hydrogel for Osteoarthritis of the Knee","abstract":"<jats:p>Background: Prior trials investigating the treatment of symptomatic osteoarthritis (OA) with hyaluronic-acid-derived products injections have provided optimistic results. The study was directed to assess the effectiveness of an innovative hyaluronic-acid-based hydrogel (Hymovis®) in the treatment of symptomatic knee OA. Methods: A prospective, single-center, clinical trial was performed. Thirty-five patients with degenerative knee OA were included. Inclusion criteria were: age between 45–80, radiographic Kellgren grade II or III osteoarthritis, minimum 35 mm score on the Visual Analogue Scale (VAS), pain for at least 6 months and agreement to participate in the study. Patients received two injections at a one-week interval. The evaluator assessed the patients using the Western Ontario and McMaster University Osteoarthritis Index (WOMAC) and VAS. Evaluation was performed before, at 2 and 6 months after the injections. Results: A significant improvement on the WOMAC Index pain subscale was observed at 6 months after the injection. At two months, pain subscale score decreased from 10.34 to 9.34. At six months, a significant decrement in pain parameters compared to baseline was observed (from 10.34 to 7.72; p = 0.0004). Median points on VAS significantly ameliorated after 6 months (from 74.2 to 57.3 cm; p &lt; 0.0001). Regarding physical function, a statistically significant difference compared to baseline was observed at the end of the study (from 29.74 to 25.18; p = 0.0025). WOMAC Index stiffness component did not differ from baseline at any time during follow-up. Conclusions: Pain relief installed with a delayed on-set but had a prolonged duration. The novel hyaluronic acid-based hydrogel (Hymovis®) had effective results, particularly after six months post-injections and offers a therapeutic advancement in the treatment of moderate to severe osteoarthritis.</jats:p>","journal":"Journal of Personalized Medicine","year":2021,"id":20555,"datarank":0.5770136990488514,"base_score":2.639057329615259,"endowment":2.639057329615259,"self_citation_contribution":0.3958585994422889,"citation_network_contribution":0.18115509960656243,"self_endowment_contribution":0.3958585994422889,"citer_contribution":0.18115509960656243,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":13,"citers_with_citation_signal":7,"citers_with_endowment":7,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":135460,"name":"Tudor Sorin Pop","orcid":null,"position":1,"is_corresponding":false},{"id":135461,"name":"Andrei Marian Feier","orcid":"0000-0002-1004-8839","position":2,"is_corresponding":false},{"id":135462,"name":"Cristian Trâmbițaș","orcid":null,"position":3,"is_corresponding":false},{"id":135463,"name":"Zsuzsanna Incze-Bartha","orcid":"0000-0003-4341-6199","position":4,"is_corresponding":false},{"id":135464,"name":"Paul Gabriel Borodi","orcid":null,"position":5,"is_corresponding":false},{"id":135465,"name":"István Gergely","orcid":null,"position":6,"is_corresponding":false},{"id":135466,"name":"Sándor-György Zuh","orcid":null,"position":7,"is_corresponding":false},{"id":135459,"name":"Octav Marius Russu","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":2.639057329615259,"endowment":2.639057329615259,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33920879","pmcid":"PMC8071312","openalex_id":"https://openalex.org/W3154425183","authors":[],"funders":[{"funder_name":"University of Medicine, Pharmacy, Sciences and Technology George Emil Palade Targu Mures","grant_id":"15270/03.11.2015","title":null}],"total_grants":1,"fwci":1.3138,"citation_percentile":0.79633566,"influential_citations":0,"citation_trend":[{"year":2021,"count":2},{"year":2023,"count":3},{"year":2024,"count":3},{"year":2025,"count":1},{"year":2026,"count":4}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.mdpi.com/2075-4426/11/4/303/pdf?version=1618478309","host_type":"journal"},{"url":"https://www.mdpi.com/2075-4426/11/4/303/pdf?version=1618478309","host_type":"GOLD"},{"url":"https://www.mdpi.com/2075-4426/11/4/303/pdf?version=1618478309","host_type":"publisher"},{"url":"https://www.mdpi.com/2075-4426/11/4/303/pdf","host_type":"publisher"},{"url":"https://doi.org/10.3390/jpm11040303","host_type":"journal"},{"url":"https://doaj.org/article/976bc3f70660489a97105068cf9fd2ac","host_type":"repository"},{"url":"https://dx.doi.org/10.3390/jpm11040303","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8071312","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC8071312","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC8071312?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Osteoarthritis Treatment and Mechanisms","Tendon Structure and Treatment","Periodontal Regeneration and Treatments","Medicine"],"mesh_terms":[],"keywords":["WOMAC","Osteoarthritis","Medicine","Visual analogue scale","Hyaluronic acid","Knee pain","Clinical trial","Physical therapy","Surgery","Internal medicine","Pathology","Intra-articular Injection"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-05T23:23:13.991526Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}