{"doi":"10.3390/jof8090931","title":"Pan-Echinocandin Resistant C. parapsilosis Harboring an F652S Fks1 Alteration in a Patient with Prolonged Echinocandin Therapy","abstract":"<jats:p>The isolation of a pan-echinocandin-resistant Candida parapsilosis strain (anidulafungin, caspofungin, micafungin and rezafungin EUCAST MICs &gt; 8 mg/L) from urine of a patient following prolonged exposure to echinocandins (38 days of micafungin followed by 16 days of anidulafungin) is described. The isolate harbored the novel alteration F652S in the hotspot 1 region of fks1. Isogenic C. parapsilosis bloodstream isolates collected up to 1.5 months earlier from the same patient were susceptible to echinocandins (anidulafungin, caspofungin and micafungin EUCAST MICs 1–2, 1 and 1 mg/L, respectively) and contained wild-type FKS1 sequences. This is the first report of pan-echinocandin resistance in C. parapsilosis associated with an aminoacid change in hotspot 1 region of fks1.</jats:p>","journal":"Journal of Fungi","year":2022,"id":16058,"datarank":1.468604663325828,"base_score":3.58351893845611,"endowment":3.58351893845611,"self_citation_contribution":0.5375278407684165,"citation_network_contribution":0.9310768225574114,"self_endowment_contribution":0.5375278407684165,"citer_contribution":0.9310768225574114,"corpus_percentile":null,"corpus_rank":null,"citation_count":35,"citer_count":32,"citers_with_citation_signal":26,"citers_with_endowment":26,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":119976,"name":"Antonios Papadopoulos","orcid":null,"position":1,"is_corresponding":false},{"id":119977,"name":"Anastasia Spiliopoulou","orcid":"0000-0001-9125-8098","position":2,"is_corresponding":false},{"id":24301,"name":"Fotini Paliogianni","orcid":"0000-0001-5112-1724","position":3,"is_corresponding":false},{"id":119980,"name":"Nissrine Abou-Chakra","orcid":null,"position":4,"is_corresponding":false},{"id":119981,"name":"Maiken Cavling Arendrup","orcid":"0000-0002-4747-0144","position":5,"is_corresponding":false},{"id":119982,"name":"Christina Damoulari","orcid":null,"position":6,"is_corresponding":false},{"id":119983,"name":"Georgios Tsioulos","orcid":null,"position":7,"is_corresponding":false},{"id":119984,"name":"Efthymia Giannitsioti","orcid":null,"position":8,"is_corresponding":false},{"id":119985,"name":"Frantzeska Frantzeskaki","orcid":null,"position":9,"is_corresponding":false},{"id":119986,"name":"Iraklis Tsangaris","orcid":"0000-0003-4395-0471","position":10,"is_corresponding":false},{"id":119987,"name":"Spyros Pournaras","orcid":null,"position":11,"is_corresponding":false},{"id":119988,"name":"Joseph Meletiadis","orcid":"0000-0002-8869-1509","position":12,"is_corresponding":false},{"id":119975,"name":"Maria Siopi","orcid":"0000-0002-5924-1007","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":3.58351893845611,"endowment":3.58351893845611,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36135656","pmcid":"PMC9502558","openalex_id":"https://openalex.org/W4294176771","authors":[],"funders":[],"total_grants":0,"fwci":3.0242,"citation_percentile":0.93119812,"influential_citations":1,"citation_trend":[{"year":2022,"count":1},{"year":2023,"count":13},{"year":2024,"count":6},{"year":2025,"count":10},{"year":2026,"count":5}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.3390/jof8090931","host_type":"journal"},{"url":"https://www.mdpi.com/2309-608X/8/9/931/pdf?version=1662022831","host_type":"GOLD"},{"url":"https://doi.org/10.3390/jof8090931","host_type":"publisher"},{"url":"https://www.mdpi.com/2309-608X/8/9/931/pdf","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/36135656","host_type":"repository"},{"url":"https://doaj.org/article/e8f59495d9e247b88c9f4b2edcaf12bc","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9502558","host_type":"repository"},{"url":"https://researchprofiles.ku.dk/da/publications/f4f28300-d7da-4aae-bf21-6d92e4c1d47c","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC9502558","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC9502558?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Antifungal resistance and susceptibility","Fungal Infections and Studies","Drug-Induced Adverse Reactions","Medicine"],"mesh_terms":[],"keywords":["Echinocandin","Medicine","Biology","Antifungal","Fluconazole","Dermatology","acquired resistance","Candida Parapsilosis","Fks1 Mutation"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-01T20:07:43.903683Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}