{"doi":"10.3390/jof7050369","title":"Long-Term Mortality after Histoplasma Infection in People with HIV","abstract":"Histoplasmosis is a common opportunistic infection in people with HIV (PWH); however, no study has looked at factors associated with the long-term mortality of histoplasmosis in PWH. We conducted a single-center retrospective study on the long-term mortality of PWH diagnosed with histoplasmosis between 2002 and 2017. Patients were categorized into three groups based on length of survival after diagnosis: early mortality (death < 90 days), late mortality (death ≥ 90 days), and long-term survivors. Patients diagnosed during or after 2008 were considered part of the modern antiretroviral therapy (ART) era. Insurance type (private vs. public) was a surrogate indicator of socioeconomic status. Out of 54 PWH infected with histoplasmosis, overall mortality was 37%; 14.8% early mortality and 22.2% late mortality. There was no statistically significant difference in survival based on the availability of modern ART (p = 0.60). Insurance status reached statistical significance with 38% of survivors having private insurance versus only 8% having private insurance in the late mortality group (p = 0.05). High mortality persists despite the advent of modern ART, implicating a contribution from social determinants of health, such as private insurance. Larger studies are needed to elucidate the role of these factors in the mortality of PWH.","journal":"Journal of Fungi","year":2021,"id":188389,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9139,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":749357,"name":"Patrick B Mazi","orcid":"0000-0003-4123-0518","position":1,"is_corresponding":false},{"id":246250,"name":"Adriana M. Rauseo","orcid":"0000-0001-9555-2550","position":2,"is_corresponding":false},{"id":750263,"name":"Chapelle Ayres","orcid":null,"position":3,"is_corresponding":false},{"id":246251,"name":"Lindsey Larson","orcid":"0000-0002-1987-9786","position":4,"is_corresponding":false},{"id":459783,"name":"Sasinuch Rutjanawech","orcid":"0000-0002-7776-2957","position":5,"is_corresponding":false},{"id":259653,"name":"Jane A. O’Halloran","orcid":"0000-0001-8265-9471","position":6,"is_corresponding":false},{"id":552303,"name":"Rachel M. Presti","orcid":"0000-0002-5469-0727","position":7,"is_corresponding":false},{"id":12011,"name":"William G. Powderly","orcid":"0000-0001-7808-3086","position":8,"is_corresponding":false},{"id":246252,"name":"Andrej Spec","orcid":"0000-0001-7612-4710","position":9,"is_corresponding":false},{"id":749356,"name":"Joseph Cherabie","orcid":"0000-0001-6945-595X","position":0,"is_corresponding":true}],"reference_count":20,"raw_metadata":null,"created_at":"2026-07-18T23:49:10.350554Z","pmid":"34066845","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}