{"doi":"10.3390/jcto3020009","title":"The Use of Ologen Collagen Matrix in Combination with XEN45 Microstent for the Treatment of Glaucoma: A Retrospective Chart Review","abstract":"Background: In this study, we compare the 12-month results of eyes that underwent ab externo, open-conjunctival XEN45 gel stent placement with mitomycin C (MMC) with and without the intraoperative addition of Ologen collagen matrix (XEN45 and XEN45 + Ologen groups, respectively). Methods: Intraocular pressure (IOP) measurements were recorded postoperation at 1 month, 3 months, 6 months, and 9 months, and 12 months, and IOP reduction, reduction in number of IOP-lowering medications, and success rate were compared between XEN45 and XEN45 + Ologen groups. A complete success was defined as a ≥20% drop from baseline IOP at 12 months without the use of medications and without any of the following: an additional procedure (e.g., needling), a recorded IOP ≥ 21 mm Hg at two consecutive visits, or the occurrence of catastrophic events (e.g., no light perception (NLP)). A qualified success was defined as an IOP reduction of ≥20% from baseline with the use of medications. We included 145 eyes with at least 1 month of follow-up data, 46 in the XEN45 group and 99 in the XEN45 + Ologen group. Of these, 113 eyes had 12 months of follow-up data comprising 41 XEN45 eyes and 72 XEN45 + Ologen eyes. Results: There were no significant differences in the IOP change from baseline between XEN45 and XEN45 + Ologen groups except at the 3-month postop timepoint (p < 0.05). At the 12-month follow-up, 41.5% (17/41) of XEN45 eyes and 52.8% (38/72) of XEN45 + Ologen eyes met complete or qualified success criteria. Conclusions: No significant differences in success rate and decrease in the number of IOP-lowering medications from baseline were identified between XEN45 and XEN45 + Ologen groups.","journal":"Journal of Clinical & Translational Ophthalmology","year":2025,"id":536169,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9649,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1421027,"name":"Marguerite Jensen","orcid":"0000-0002-6916-6354","position":1,"is_corresponding":false},{"id":1007271,"name":"John A. Musser","orcid":null,"position":2,"is_corresponding":false},{"id":1156319,"name":"Neil Kelkar","orcid":null,"position":3,"is_corresponding":false},{"id":1155907,"name":"Kevin Eid","orcid":"0000-0002-7608-0268","position":4,"is_corresponding":false},{"id":880884,"name":"Ryan T. Wallace","orcid":"0000-0002-0206-2091","position":5,"is_corresponding":false},{"id":757014,"name":"Cole Swiston","orcid":"0000-0003-0006-893X","position":6,"is_corresponding":false},{"id":455317,"name":"Ben J. Brintz","orcid":"0000-0003-4695-0290","position":7,"is_corresponding":false},{"id":1421028,"name":"Austin S. Nakatsuka","orcid":"0000-0002-4058-4763","position":8,"is_corresponding":false},{"id":467236,"name":"Brian C. Stagg","orcid":"0000-0003-4023-1885","position":9,"is_corresponding":false},{"id":1006925,"name":"Craig J. Chaya","orcid":"0000-0003-2730-6133","position":10,"is_corresponding":false},{"id":1096379,"name":"Catherine A Johnson","orcid":null,"position":0,"is_corresponding":true}],"reference_count":24,"raw_metadata":null,"created_at":"2026-07-19T02:52:05.227140Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}