{"doi":"10.3390/jcm13206218","title":"Associations Between High-Density Lipoprotein Cholesterol Efflux and Brain Grey Matter Volume","abstract":"Objective: High-density lipoprotein cholesterol efflux function may prevent brain amyloid beta deposition and neurodegeneration. However, the relevance of this finding has not been established in the diverse middle-aged population. Methods: We examined 1826 adults (47% Black adults) who participated in the Dallas Heart Study to determine associations between high-density lipoprotein (HDL) measures and brain structure and function. White matter hyperintensities (WMH) and whole-brain grey matter volume (GMV) were measured using brain MRI, and the Montreal Cognitive Assessment (MoCA) was used to measure neurocognitive function. HDL cholesterol efflux capacity (HDL-CEC) was assessed using fluorescence-labeled cholesterol efflux from J774 macrophages, and HDL particle size measures were assessed using nuclear magnetic resonance (NMR) spectroscopy (LipoScience). Multivariable linear regressions were performed to elucidate associations between HDL-CEC and brain and cognitive phenotypes after adjustment for traditional risk factors such as age, smoking status, time spent in daily physical activity, and education level. Results: Higher HDL-CEC and small HDL particle (HDL-P) concentration were positively associated with higher GMV normalized to total cranial volume (TCV) (GMV/TCV) after adjustment for relevant risk factors (β = 0.078 [95% CI: 0.029, 0.126], p = 0.002, and β = 0.063 [95% CI: 0.014, 0.111], p = 0.012, respectively). Conversely, there were no associations between HDL measures and WMH or MoCA (all p > 0.05). Associations of HDL-CEC and small HDL-P with GMV/TCV were not modified by ApoE-ε4 status or race/ethnicity. Interpretation: Higher HDL cholesterol efflux and higher plasma concentration of small HDL-P were associated with higher GMV/TCV. Additional studies are needed to explore the potential neuroprotective functions of HDL.","journal":"Journal of Clinical Medicine","year":2024,"id":447692,"datarank":0.29188652235829704,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.0,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9618,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":758216,"name":"Jijia Wang","orcid":"0000-0003-2882-7520","position":1,"is_corresponding":false},{"id":348513,"name":"Rong Zhang","orcid":"0000-0002-6534-5216","position":2,"is_corresponding":false},{"id":688948,"name":"Brendan Kelley","orcid":"0000-0002-3440-5191","position":3,"is_corresponding":false},{"id":74595,"name":"Ihab Hajjar","orcid":"0000-0001-6096-5304","position":4,"is_corresponding":false},{"id":312128,"name":"Binu P. Thomas","orcid":"0000-0002-3882-3251","position":5,"is_corresponding":false},{"id":570313,"name":"Fang Yu","orcid":"0000-0001-9913-1331","position":6,"is_corresponding":false},{"id":331315,"name":"James A. de Lemos","orcid":"0000-0003-2211-7261","position":7,"is_corresponding":false},{"id":293943,"name":"Anand Rohatgi","orcid":"0000-0003-0164-2382","position":8,"is_corresponding":false},{"id":454402,"name":"Wanpen Vongpatanasin","orcid":"0000-0002-7531-9388","position":9,"is_corresponding":false},{"id":981445,"name":"John M. Giacona","orcid":"0000-0003-0334-9876","position":0,"is_corresponding":true}],"reference_count":51,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:02:03.354708Z","pmid":"39458168","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}