{"doi":"10.3390/jcm13113254","title":"Gut Microbiota Dysbiosis and Sleep Disorders: Culprit in Cardiovascular Diseases","abstract":"<jats:p>Background: Over the past decade, the gut microbiome (GM) has progressively demonstrated to have a central role in human metabolism, immunity, and cardiometabolic risk. Likewise, sleep disorders showed an impact on individual health and cardiometabolic risk. Recent studies seem to suggest multi-directional relations among GM, diet, sleep, and cardiometabolic risk, though specific interactions are not fully elucidated. We conducted a systematic review to synthesize the currently available evidence on the potential interactions between sleep and GM and their possible implications on cardiometabolic risk. Methods: A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement for reporting systematic reviews and meta-analyses, including articles from January 2016 until November 2022. Narrative syntheses were employed to describe the results. Results: A total of 8 studies were selected according to these criteria. Our findings indicated that the sleep disorder and/or the acute circadian rhythm disturbance caused by sleep–wake shifts affected the human GM, mainly throughout microbial functionality. Conclusions: Sleep disorders should be viewed as cardiovascular risk factors and targeted for preventive intervention. More research and well-designed studies are needed to completely assess the role of sleep deprivation in the multi-directional relationship between GM and cardiometabolic risk.</jats:p>","journal":"Journal of Clinical Medicine","year":2024,"id":632257,"datarank":0.4493598410330987,"base_score":2.995732273553991,"endowment":2.995732273553991,"self_citation_contribution":0.4493598410330987,"citation_network_contribution":0.0,"self_endowment_contribution":0.4493598410330987,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":19,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1638803,"name":"Laura Pennazzi","orcid":null,"position":1,"is_corresponding":false},{"id":1638804,"name":"Giulia Nardoianni","orcid":"0000-0001-6861-6870","position":2,"is_corresponding":false},{"id":1214338,"name":"Federica Fogacci","orcid":"0000-0001-7853-0042","position":3,"is_corresponding":false},{"id":842396,"name":"Arrigo F.G. Cicero","orcid":"0000-0002-4367-3884","position":4,"is_corresponding":false},{"id":1638805,"name":"Laura Di Renzo","orcid":"0000-0001-8875-6723","position":5,"is_corresponding":false},{"id":84509,"name":"Emanuele Barbato","orcid":"0000-0002-0050-5178","position":6,"is_corresponding":false},{"id":1286711,"name":"Giuliano Tocci","orcid":"0000-0002-0635-4921","position":7,"is_corresponding":false},{"id":1638802,"name":"Barbara Pala","orcid":"0000-0002-7359-4028","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Gut Microbiota Dysbiosis and Sleep Disorders: Culprit in Cardiovascular Diseases","abstract":"<jats:p>Background: Over the past decade, the gut microbiome (GM) has progressively demonstrated to have a central role in human metabolism, immunity, and cardiometabolic risk. Likewise, sleep disorders showed an impact on individual health and cardiometabolic risk. Recent studies seem to suggest multi-directional relations among GM, diet, sleep, and cardiometabolic risk, though specific interactions are not fully elucidated. We conducted a systematic review to synthesize the currently available evidence on the potential interactions between sleep and GM and their possible implications on cardiometabolic risk. Methods: A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement for reporting systematic reviews and meta-analyses, including articles from January 2016 until November 2022. Narrative syntheses were employed to describe the results. Results: A total of 8 studies were selected according to these criteria. Our findings indicated that the sleep disorder and/or the acute circadian rhythm disturbance caused by sleep–wake shifts affected the human GM, mainly throughout microbial functionality. Conclusions: Sleep disorders should be viewed as cardiovascular risk factors and targeted for preventive intervention. More research and well-designed studies are needed to completely assess the role of sleep deprivation in the multi-directional relationship between GM and cardiometabolic risk.</jats:p>","is_dataset_classified":null,"base_score":2.995732273553991,"endowment":2.995732273553991,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38892965","pmcid":"PMC11173264","openalex_id":"https://openalex.org/W4399208094","authors":[],"funders":[],"total_grants":0,"fwci":3.1215,"citation_percentile":0.92637838,"influential_citations":0,"citation_trend":[{"year":2024,"count":3},{"year":2025,"count":10},{"year":2026,"count":6}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.mdpi.com/2077-0383/13/11/3254/pdf?version=1717160579","host_type":"journal"},{"url":"https://www.mdpi.com/2077-0383/13/11/3254/pdf?version=1717160579","host_type":"publisher"},{"url":"https://www.mdpi.com/2077-0383/13/11/3254/pdf","host_type":"publisher"},{"url":"https://doi.org/10.3390/jcm13113254","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38892965","host_type":"repository"},{"url":"https://www.mdpi.com/2077-0383/13/11/3254","host_type":"repository"},{"url":"https://hdl.handle.net/11573/1712104","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11173264","host_type":"repository"},{"url":"https://dx.doi.org/10.3390/jcm13113254","host_type":"repository"},{"url":"https://iris.uniroma1.it/bitstream/11573/1712104/1/Pala_Gut-microbiota_2024.pdf","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11173264/pdf/jcm-13-03254.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC11173264","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC11173264?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Gut microbiota and health","Diet and metabolism studies","Health, psychology, and well-being"],"mesh_terms":[],"keywords":["Medicine","Systematic review","Sleep deprivation","Dysbiosis","Sleep (system call)","Gut flora","Culprit","Microbiome","Sleep restriction","Gut microbiome","Circadian rhythm","Bioinformatics","Intensive care medicine","MEDLINE","Psychiatry","Internal medicine","Immunology","Sleep disorders","Cardiovascular Risk","Prisma","Cardiometabolic Risk"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T09:20:06.542996Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}