{"doi":"10.3390/jcm13010245","title":"Diabetes Status, c-Reactive Protein, and Insulin Resistance in Community-Acquired Pneumonia—A Prospective Cohort Study","abstract":"<jats:p>C-reactive protein (CRP) is commonly used to guide community-acquired pneumonia (CAP) treatment. A positive association between admission glucose and CRP levels has been observed in patients with CAP. The associations between prediabetes, unknown diabetes, acute-on-chronic hyperglycaemia, and CRP levels, and between admission CRP levels and insulin resistance (IR) in CAP, remain unexplored. This study investigated the associations firstly between chronic, acute, and acute-on-chronic hyperglycaemia and CRP levels, and secondly between admission CRP levels and IR in CAP. In a prospective cohort study of adults with CAP, the associations between chronic, acute, and acute-on-chronic hyperglycaemia (admission glucose minus HbA1c-derived average glucose) and CRP levels until admission day 3 were modelled with repeated-measures linear mixed models. IR was estimated with the homeostasis model assessment of IR (HOMA-IR). The association between admission CRP levels and HOMA-IR was modelled with linear regression. In 540 patients, no association between chronic, acute, or acute-on-chronic hyperglycaemia and CRP levels was found. In 266 patients, every 50 mg/L increase in admission CRP was associated with a 7% (95% CI 1–14%) higher HOMA-IR. In conclusion, our findings imply that hyperglycaemia does not influence CRP levels in patients with CAP, although admission CRP levels were positively associated with IR.</jats:p>","journal":"Journal of Clinical Medicine","year":2023,"id":603049,"datarank":0.29188652235829704,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.0,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1546865,"name":"Camilla Koch Ryrsø","orcid":"0000-0002-8059-7331","position":1,"is_corresponding":false},{"id":1546866,"name":"Maria Hein Hegelund","orcid":"0000-0001-6287-1619","position":2,"is_corresponding":false},{"id":846089,"name":"Andreas Vestergaard Jensen","orcid":"0000-0002-8532-4703","position":3,"is_corresponding":false},{"id":34497,"name":"Peter Lommer Kristensen","orcid":"0000-0001-5431-824X","position":4,"is_corresponding":false},{"id":318238,"name":"Rikke Krogh‐Madsen","orcid":"0000-0003-4914-2715","position":5,"is_corresponding":false},{"id":493615,"name":"Christian Ritz","orcid":"0000-0002-5095-0624","position":6,"is_corresponding":false},{"id":318235,"name":"Daniel Faurholt‐Jepsen","orcid":"0000-0001-8561-0155","position":7,"is_corresponding":false},{"id":846087,"name":"Birgitte Lindegaard","orcid":"0000-0002-5236-8427","position":8,"is_corresponding":false},{"id":1546864,"name":"Arnold Matovu Dungu","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Diabetes Status, c-Reactive Protein, and Insulin Resistance in Community-Acquired Pneumonia—A Prospective Cohort Study","abstract":"<jats:p>C-reactive protein (CRP) is commonly used to guide community-acquired pneumonia (CAP) treatment. A positive association between admission glucose and CRP levels has been observed in patients with CAP. The associations between prediabetes, unknown diabetes, acute-on-chronic hyperglycaemia, and CRP levels, and between admission CRP levels and insulin resistance (IR) in CAP, remain unexplored. This study investigated the associations firstly between chronic, acute, and acute-on-chronic hyperglycaemia and CRP levels, and secondly between admission CRP levels and IR in CAP. In a prospective cohort study of adults with CAP, the associations between chronic, acute, and acute-on-chronic hyperglycaemia (admission glucose minus HbA1c-derived average glucose) and CRP levels until admission day 3 were modelled with repeated-measures linear mixed models. IR was estimated with the homeostasis model assessment of IR (HOMA-IR). The association between admission CRP levels and HOMA-IR was modelled with linear regression. In 540 patients, no association between chronic, acute, or acute-on-chronic hyperglycaemia and CRP levels was found. In 266 patients, every 50 mg/L increase in admission CRP was associated with a 7% (95% CI 1–14%) higher HOMA-IR. In conclusion, our findings imply that hyperglycaemia does not influence CRP levels in patients with CAP, although admission CRP levels were positively associated with IR.</jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38202252","pmcid":"PMC10780000","openalex_id":"https://openalex.org/W38202252","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.00731549,"influential_citations":0,"citation_trend":[],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.mdpi.com/2077-0383/13/1/245/pdf?version=1704006365","host_type":"publisher"},{"url":"https://www.mdpi.com/2077-0383/13/1/245/pdf","host_type":"publisher"},{"url":"https://cyberleninka.ru/article/n/romah-o-v-ot-nauchnogo-redaktora","host_type":"journal"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10780000/pdf/jcm-13-00245.pdf","host_type":"repository"},{"url":"https://findresearcher.sdu.dk/ws/files/254837172/jcm-13-00245.pdf","host_type":"repository"},{"url":"https://researchprofiles.ku.dk/da/publications/62d46e36-7090-443f-ae8a-9ff5a58ff9d6","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC10780000","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC10780000?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Hyperglycemia and glycemic control in critically ill and hospitalized patients","Pneumonia and Respiratory Infections","Sepsis Diagnosis and Treatment"],"mesh_terms":[],"keywords":["Environmental science","Diabetes mellitus","Insulin resistance","Community-acquired pneumonia","C-reactive Protein","Chronic Hyperglycaemia","Acute-On-Chronic Hyperglycaemia","Acute Hyperglycaemia"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T20:58:27.792411Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}