{"doi":"10.3390/jcm12072691","title":"Reliability and Validity of Single Axial Slice vs. Multiple Slice Quantitative Measurement of the Volume of Effusion-Synovitis on 3T Knee MRI in Knees with Osteoarthritis","abstract":"Effusion-synovitis (ES) is recognized as a component of osteoarthritis, creating a need for rapid methods to assess ES on MRI. We describe the development and reliability of an efficient single-slice semi-automated quantitative approach to measure ES. We used two samples from the Osteoarthritis Initiative (OAI): 50 randomly selected OAI participants with radiographic osteoarthritis (i.e., Kellgren–Lawrence (KL) grade 2 or 3) and a subset from the Foundation for the National Institutes of Health Osteoarthritis Biomarker study. An experienced musculoskeletal radiologist trained four non-expert readers to use custom semi-automated software to measure ES on a single axial slice and then read scans blinded to prior assessments. The estimated intraclass correlation coefficient (ICC) for intra-reader reliability of the single-slice ES method in the KL 2–3 sample was 0.96 (95% CI: 0.93, 0.97), and for inter-reader reliability, the ICC was 0.90 (95% CI: 0.87, 0.95). The intra-reader mean absolute difference (MAD) was 35 mm3 (95% CI: 28, 44), and the inter-reader MAD was 61 mm3 (95% CI: 48, 76). Our single-slice quantitative knee ES measurement offers a reliable, valid, and efficient surrogate for multi-slice quantitative and semi-quantitative assessment.","journal":"Journal of Clinical Medicine","year":2023,"id":368902,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.944,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1127258,"name":"Arjun Vohra","orcid":"0000-0002-4758-431X","position":1,"is_corresponding":false},{"id":946418,"name":"Dagoberto Robles","orcid":"0000-0002-9073-810X","position":2,"is_corresponding":false},{"id":1123392,"name":"Mihra S. Taljanovic","orcid":"0000-0003-1910-6545","position":3,"is_corresponding":false},{"id":1127661,"name":"Erin L. Ashbeck","orcid":null,"position":4,"is_corresponding":false},{"id":1127662,"name":"Chelsea Caruso","orcid":null,"position":5,"is_corresponding":false},{"id":483771,"name":"J. Duryea","orcid":null,"position":6,"is_corresponding":false},{"id":347985,"name":"Edward J. Bedrick","orcid":"0000-0002-4215-795X","position":7,"is_corresponding":false},{"id":313864,"name":"Ali Guermazi","orcid":"0000-0002-9374-8266","position":8,"is_corresponding":false},{"id":325671,"name":"C. Kent Kwoh","orcid":"0000-0001-5937-550X","position":9,"is_corresponding":false},{"id":1127257,"name":"Greg Gilles","orcid":"0009-0005-2577-2116","position":0,"is_corresponding":true}],"reference_count":48,"raw_metadata":null,"created_at":"2026-07-19T01:15:24.517012Z","pmid":"37048775","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}