{"doi":"10.3390/jcm12051906","title":"Hyperglycemia and Glycemic Variability Associated with Glucocorticoids in Women without Pre-Existing Diabetes Undergoing Neoadjuvant or Adjuvant Taxane Chemotherapy for Early-Stage Breast Cancer","abstract":"Glucocorticoids, which are administered with chemotherapy, cause hyperglycemia. Glycemic variability among breast cancer patients without diabetes is not well known. A retrospective cohort study was conducted involving early-stage breast cancer patients without diabetes who received dexamethasone prior to neoadjuvant or adjuvant taxane chemotherapy between August 2017–December 2019. Random blood glucose levels were analyzed, and steroid-induced hyperglycemia (SIH) was defined as a random glucose level of >140 mg/dL. A multivariate proportional hazards model was used to identify the risk factors of SIH. Out of 100 patients, the median age was 53 years (IQR: 45–63.5). A total of 45% of patients were non-Hispanic White, 28% Hispanic, 19% Asian, and 5% African American. The incidence of SIH was 67%, and glycemic fluctuations were highest in those with glucose levels of >200 mg/dL. Non-Hispanic White patients represented a significant predictor for time to SIH, with a hazard ratio of 2.5 (95% CI: 1.04, 5.95, p = 0.039). SIH was transient in over 90% of the patients, and only seven patients remained hyperglycemic after glucocorticoid and chemotherapy completion. Pretaxane dexamethasone-induced hyperglycemia was observed in 67% of the patients, with the greatest glycemic lability in those patients with blood glucose levels of >200 mg/dL. The non-Hispanic White patients had a higher risk of developing SIH.","journal":"Journal of Clinical Medicine","year":2023,"id":356125,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9456,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":992882,"name":"Sayeh Lavasani","orcid":null,"position":1,"is_corresponding":false},{"id":1105275,"name":"Leon Cristobal","orcid":null,"position":2,"is_corresponding":false},{"id":1105276,"name":"Niki Tank Patel","orcid":null,"position":3,"is_corresponding":false},{"id":343840,"name":"Mina S. Sedrak","orcid":"0000-0002-8379-391X","position":4,"is_corresponding":false},{"id":461451,"name":"Daphne Stewart","orcid":"0000-0001-9845-8375","position":5,"is_corresponding":false},{"id":294149,"name":"James Waisman","orcid":"0000-0003-2896-4146","position":6,"is_corresponding":false},{"id":443405,"name":"Yuan Yuan","orcid":"0000-0001-7440-8939","position":7,"is_corresponding":false},{"id":1105277,"name":"Wai Yu","orcid":null,"position":8,"is_corresponding":false},{"id":881934,"name":"Raynald Samoa","orcid":"0000-0002-7208-8764","position":9,"is_corresponding":false},{"id":395167,"name":"Nora Ruel","orcid":"0000-0002-4591-3618","position":10,"is_corresponding":false},{"id":461448,"name":"Susan E. Yost","orcid":"0000-0002-9422-0316","position":11,"is_corresponding":false},{"id":1105278,"name":"Hayley Lee","orcid":null,"position":12,"is_corresponding":false},{"id":717715,"name":"Sung Hee Kil","orcid":"0000-0001-5152-6692","position":13,"is_corresponding":false},{"id":288920,"name":"Joanne Mortimer","orcid":"0000-0002-2935-1934","position":14,"is_corresponding":false},{"id":1105274,"name":"Dana Mahin","orcid":null,"position":0,"is_corresponding":true}],"reference_count":45,"raw_metadata":null,"created_at":"2026-07-19T01:13:25.429924Z","pmid":"36902693","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}