{"doi":"10.3390/jcm12051788","title":"Deprescribing Strategies for Opioids and Benzodiazepines with Emphasis on Concurrent Use: A Scoping Review","abstract":"While the Food and Drug Administration's black-box warnings caution against concurrent opioid and benzodiazepine (OPI-BZD) use, there is little guidance on how to deprescribe these medications. This scoping review analyzes the available opioid and/or benzodiazepine deprescribing strategies from the PubMed, EMBASE, Web of Science, Scopus, and Cochrane Library databases (01/1995-08/2020) and the gray literature. We identified 39 original research studies (opioids: n = 5, benzodiazepines: n = 31, concurrent use: n = 3) and 26 guidelines (opioids: n = 16, benzodiazepines: n = 11, concurrent use: n = 0). Among the three studies deprescribing concurrent use (success rates of 21-100%), two evaluated a 3-week rehabilitation program, and one assessed a 24-week primary care intervention for veterans. Initial opioid dose deprescribing rates ranged from (1) 10-20%/weekday followed by 2.5-10%/weekday over three weeks to (2) 10-25%/1-4 weeks. Initial benzodiazepine dose deprescribing rates ranged from (1) patient-specific reductions over three weeks to (2) 50% dose reduction for 2-4 weeks, followed by 2-8 weeks of dose maintenance and then a 25% reduction biweekly. Among the 26 guidelines identified, 22 highlighted the risks of co-prescribing OPI-BZD, and 4 provided conflicting recommendations on the OPI-BZD deprescribing sequence. Thirty-five states' websites provided resources for opioid deprescription and three states' websites had benzodiazepine deprescribing recommendations. Further studies are needed to better guide OPI-BZD deprescription.","journal":"Journal of Clinical Medicine","year":2023,"id":342315,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9549,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":316903,"name":"Debbie L. Wilson","orcid":"0000-0002-1640-5497","position":1,"is_corresponding":false},{"id":1079303,"name":"Deanna Fernandes","orcid":null,"position":2,"is_corresponding":false},{"id":586728,"name":"Lauren Adkins","orcid":"0000-0002-0914-2086","position":3,"is_corresponding":false},{"id":1079304,"name":"Ashley Bantad","orcid":null,"position":4,"is_corresponding":false},{"id":1078822,"name":"Clint Copacia","orcid":"0000-0002-5379-1278","position":5,"is_corresponding":false},{"id":1079305,"name":"Nilay Dharma","orcid":null,"position":6,"is_corresponding":false},{"id":1078823,"name":"Pei‐Lin Huang","orcid":"0000-0001-7861-3745","position":7,"is_corresponding":false},{"id":1050296,"name":"Amanda Joseph","orcid":null,"position":8,"is_corresponding":false},{"id":669612,"name":"Tae Woo Park","orcid":"0000-0002-1930-1343","position":9,"is_corresponding":false},{"id":458359,"name":"Jeffrey Budd","orcid":"0000-0002-6816-6619","position":10,"is_corresponding":false},{"id":1079306,"name":"Senthil Meenrajan","orcid":null,"position":11,"is_corresponding":false},{"id":747022,"name":"Frank A. Orlando","orcid":"0000-0003-4924-1035","position":12,"is_corresponding":false},{"id":1079307,"name":"John Pennington","orcid":null,"position":13,"is_corresponding":false},{"id":232079,"name":"Siegfried Schmidt","orcid":"0000-0001-5941-6009","position":14,"is_corresponding":false},{"id":364880,"name":"Ronald I. Shorr","orcid":"0000-0002-1457-4668","position":15,"is_corresponding":false},{"id":929952,"name":"Constance R. Uphold","orcid":"0000-0001-5230-6480","position":16,"is_corresponding":false},{"id":491952,"name":"Wei‐Hsuan Lo‐Ciganic","orcid":"0000-0001-6590-4770","position":17,"is_corresponding":false},{"id":1078821,"name":"Yanning Wang","orcid":"0000-0002-4263-3944","position":0,"is_corresponding":true}],"reference_count":90,"raw_metadata":null,"created_at":"2026-07-19T01:11:12.506815Z","pmid":"36902574","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}