{"doi":"10.3390/jcm11123547","title":"Upregulation of Endothelin-1 May Predict Chemotherapy-Induced Cardiotoxicity in Women with Breast Cancer","abstract":"As survival in breast cancer patients from newer therapies increases, concerns for chemotherapy-induced cardiotoxicity (CIC) have offset some of these benefits, manifesting as a decline in left ventricular ejection fraction (LVEF). Patients receiving anthracycline-based chemotherapy followed by trastuzumab are at risk for CIC. Previous research evaluating whether clinical biomarkers predict cardiotoxicity has been inconsistent. Recently, angiotensin II type 1 receptor (ATR1) and endothelin 1 (ET1) have been shown to play a role in breast tumor growth. We evaluated ATR1 and ET1 expression in breast cancer tissue and its association with CIC. A total of 33 paraffin-embedded breast tissue specimens from women with breast cancer treated with anthracycline-based chemotherapy and trastuzumab were analyzed by immunohistochemistry (IHC) and qRT-PCR. We found that ET1 expression was increased in patients with an LVEF ≤ 50% (p = 0.032) with a lower LVEF correlating with higher ET1 expression (r = 0.377, p = 0.031). In patients with a change in LVEF of greater than 10%, greater ET1 expression was noted compared to those without a change in LVEF (p = 0.017). Increased ET1 expression in breast tumor tissue is associated with reduced LVEF. Future studies need to examine whether ET1 may be a tissue biomarker that helps predict the risk of developing CIC in women with breast cancer.","journal":"Journal of Clinical Medicine","year":2022,"id":270942,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.953,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":40577,"name":"Katelyn A. Bruno","orcid":"0000-0001-8980-6059","position":1,"is_corresponding":false},{"id":248039,"name":"Damian N. Di Florio","orcid":"0000-0003-1619-5394","position":2,"is_corresponding":false},{"id":495956,"name":"Brandy Edenfield","orcid":"0009-0005-5571-9500","position":3,"is_corresponding":false},{"id":734052,"name":"Emily R. Whelan","orcid":"0000-0002-0410-0549","position":4,"is_corresponding":false},{"id":734506,"name":"Logan P. Macomb","orcid":null,"position":5,"is_corresponding":false},{"id":903317,"name":"Molly M. McGuire","orcid":null,"position":6,"is_corresponding":false},{"id":507466,"name":"Anneliese R. Hill","orcid":null,"position":7,"is_corresponding":false},{"id":506477,"name":"Jordan Ray","orcid":"0000-0001-7583-3355","position":8,"is_corresponding":false},{"id":935724,"name":"Lauren Cornell","orcid":"0000-0002-9121-0892","position":9,"is_corresponding":false},{"id":263984,"name":"Winston Tan","orcid":"0000-0003-4706-0310","position":10,"is_corresponding":false},{"id":936360,"name":"Xochiquetzal J. Geiger","orcid":null,"position":11,"is_corresponding":false},{"id":494597,"name":"Gary R. Salomon","orcid":null,"position":12,"is_corresponding":false},{"id":681960,"name":"Erika J. Douglass","orcid":"0000-0002-7769-6726","position":13,"is_corresponding":false},{"id":248042,"name":"DeLisa Fairweather","orcid":"0000-0003-3093-1810","position":14,"is_corresponding":false},{"id":681963,"name":"Mohamad H. Yamani","orcid":"0000-0002-3567-8773","position":15,"is_corresponding":false},{"id":935723,"name":"Krithika Krishnarao","orcid":"0000-0001-8098-2814","position":0,"is_corresponding":true}],"reference_count":53,"raw_metadata":null,"created_at":"2026-07-19T00:27:35.206187Z","pmid":"35743613","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}