{"doi":"10.3390/jcdd7030031","title":"Dynamic Expression Profiles of β-Catenin during Murine Cardiac Valve Development","abstract":"β-catenin has been widely studied in many animal and organ systems across evolution, and gain or loss of function has been linked to a number of human diseases. Yet fundamental knowledge regarding its protein expression and localization remains poorly described. Thus, we sought to define whether there was a temporal and cell-specific regulation of β-catenin activities that correlate with distinct cardiac morphological events. Our findings indicate that activated nuclear β-catenin is primarily evident early in gestation. As development proceeds, nuclear β-catenin is down-regulated and becomes restricted to the membrane in a subset of cardiac progenitor cells. After birth, little β-catenin is detected in the heart. The co-expression of β-catenin with its main transcriptional co-factor, Lef1, revealed that Lef1 and β-catenin expression domains do not extensively overlap in the cardiac valves. These data indicate mutually exclusive roles for Lef1 and β-catenin in most cardiac cell types during development. Additionally, these data indicate diverse functions for β-catenin within the nucleus and membrane depending on cell type and gestational timing. Cardiovascular studies should take into careful consideration both nuclear and membrane β-catenin functions and their potential contributions to cardiac development and disease.","journal":"Journal of Cardiovascular Development and Disease","year":2020,"id":113379,"datarank":0.24141568686511508,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.0,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.942,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":439687,"name":"Janiece Glover","orcid":"0000-0002-5781-5572","position":1,"is_corresponding":false},{"id":535159,"name":"Alyssa Risner","orcid":"0000-0002-4171-4320","position":2,"is_corresponding":false},{"id":430960,"name":"Christina Wang","orcid":"0000-0003-1493-5723","position":3,"is_corresponding":false},{"id":439685,"name":"Diana Fulmer","orcid":"0000-0001-7675-9951","position":4,"is_corresponding":false},{"id":430958,"name":"Kelsey Moore","orcid":"0000-0002-3214-7010","position":5,"is_corresponding":false},{"id":260338,"name":"Cortney Gensemer","orcid":"0000-0002-8492-3536","position":6,"is_corresponding":false},{"id":440804,"name":"Mary Kate Rumph","orcid":null,"position":7,"is_corresponding":false},{"id":430959,"name":"Reece Moore","orcid":"0000-0002-2809-0429","position":8,"is_corresponding":false},{"id":439691,"name":"Tyler Beck","orcid":"0000-0002-1717-8943","position":9,"is_corresponding":false},{"id":260341,"name":"Russell A. Norris","orcid":"0000-0001-8462-5726","position":10,"is_corresponding":false},{"id":439688,"name":"Lilong Guo","orcid":"0000-0001-9376-3274","position":0,"is_corresponding":true}],"reference_count":86,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:13:21.458038Z","pmid":"32824435","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}